Thank you @MichaelDJain! indeed myeloid cells appear to be critical for CART cell antitumor activity!
Great review by @kenderian_ss on the conflicting role of myeloid cells in CAR T. IMO mice models tend to show that myeloid cells “help” and need activation while in patients it seems the myeloid cells are suppressive/inflamed and need to be reduced.View quoted post on X
pubmed.ncbi.nlm.nih.gov/41817579/