Yale School of Medicine

A new experimental procedure developed by researchers at Yale School of Medicine could help scientists better understand how #DNA structure influences #disease and development.

Understanding the relationship between the 3D genome and epigenetics has implications for DNA function and disease. However, most methods struggle to combine these two factors. Now, a new method published Nov. 5 in Nature Methods provides an unparalleled look at the interactions between these two aspects of DNA structure by providing a high-resolution profile of epigenetic marks and the 3D genome in single cells.

Read more here: medicine.yale.edu/news-article/h…

A family impacted by type 1 diabetes for generations has gifted $10 million to Yale. That commitment has now resulted in a $10 million gift to Yale School of Medicine (YSM) to fund a five-year, multi-investigator research program focused on reversing and ultimately curing type 1 diabetes. Anastasia and Igor Bukhman made the gift through the Bukhman Foundation to be part of the work that could impact their daughter’s life and future generations to come.

“The gift funds a number of projects which are all focused on stopping the immune-mediated pathogenesis of type 1 diabetes and restoring lost insulin-producing beta cells,” says Kevan Herold, MD, the C.N.H. Long Professor of Immunobiology and of Medicine (Endocrinology).

medicine.yale.edu/news-article/y…

#NationalDiabetesMonth #type1diabetes #juvenilediabetes @YaleIMed

Precision medicine for cancer seeks to match treatment to the genetic changes found in a patient’s tumor. A new Yale study suggests that for melanoma there may be an important clue to consider: the patient’s age.

In the study published Nov. 6 in Science Advances, researchers found that one #melanoma mutation in a gene called #BRAF showed greater growth and persistence in #tumors from younger patients but declined at older ages. Mutations in another #cancer-associated gene, NRAS, showed the opposite trend, becoming more prominent with age.

medicine.yale.edu/news-article/p…

More than 36 million Americans have #type2diabetes, a condition primarily attributed to the body’s cells not responding to #insulin properly, leading to high blood sugar levels. Due to the concomitant increase in the prevalence of #obesity, type 2 diabetes is rising across the U.S. and around the world.

Research shows that most cases of type 2 #diabetes can be prevented through lifestyle interventions. But if you already have the condition, can it be reversed?

Read here: medicine.yale.edu/news-article/c…

The link between #cannabis and its effects on mental health, particularly #schizophrenia, continues to spark debate. While many tout marijuana’s calming effects, particularly in online forums, mental health experts caution against its use - especially among young people. Research increasingly reveals a concerning relationship between cannabis use and #psychotic disorders like schizophrenia.

Read more here: medicine.yale.edu/news-article/b…

#mentalhealth #marijuana