Bosch Lab

@ABoschLab

Gene Therapy for Neurometabolic Diseases Lab at @INC_UAB

Joined June 2024

57 Following 8 Followers 15 Posts

Latest posts 5

Bosch Lab @ABoschLab Oct 14, 2025

🚀 Our lab had a strong presence at #ESGCT × #SETGYC in Sevilla!
Talk on ALS, posters on gene therapy for PNS regeneration, MLC1 & Wolfram syndrome, plus @MiguelChillonLab on SPG52, GNB1 & HEBE chimeric protein.
Wrapped up with feria-style tapas & music! 🎶

Bosch Lab @ABoschLab Sep 14, 2025

Just out: a comprehensive review of gene therapies in ALS – covering neuroprotection, ASOs, RNAi, CRISPR etc.; includes tables summarizing preclinical & clinical data, discusses hurdles & latest trial outcomes.

🔗Read more: liebertpub.com/doi/full/10.11…

Bosch Lab @ABoschLab Mar 17, 2025

🔬🧬 Our latest paper has just been published in Molecular Therapy (@MolTherapy)! In this study, conducted at @INC_UAB @UABBarcelona , we developed an intravenous gene therapy for MLC, an ultrarare leukodystrophy.

cell.com/molecular-ther…

www.cell.com Gene therapy rescues brain edema and motor function in a mouse model of megalencephalic leukoence... Bosch and colleagues demonstrate that astrocyte-specific AAV gene therapy restores MLC1 expression, reverses white matter vacuolation, and improves motor function in Mlc1−/− mice for up to 1 year....

Bosch Lab @ABoschLab Oct 31, 2024

Our PI participated in the 9th Annual Wolfram Syndrome Research Symposium where she gave a talk on our latest findings. Thank you to the Snow Foundation for organizing this impactful event. We appreciate the opportunity to engage with the community!

🔗 shorturl.at/yci0p

Bosch Lab @ABoschLab Oct 30, 2024

Last week at #ESGCT2024 was incredible! Our team, alongside the Gene Therapy for CNS lab, showcased our work with 3 posters on gene therapies for rare diseases: MLC, SPG52, and ALS. It's always exciting to contribute to the future of the field and connect with colleagues!