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American Registry of Pathology Press: Home of the AFIP Fascicles

arppress.org Joined May 2016

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ARP Press @ARP_Press Oct 30

More from arppress.org/books/book/26:
Lacrimal gland ductal cyst (dacryops) is an uncommon cystic lesion that can occur anywhere lacrimal gland tissue is present, but most commonly occurs in the palpebral lobe of the lacrimal gland. Microscopically, the cyst is lined by a bilayer of cuboidal to columnar cells with goblet cells.

#OcularPath

DACRYOPS:
A large dilated duct is present to the right of the lacrimal gland tissue (H&E stain).

ARP Press @ARP_Press Oct 17

You all are correct! This is encapsulated papillary carcinoma, typically presenting as a single tumor nodule with a thick fibrous capsule; most are low or intermediate nuclear grade. Pure encapsulated papillary carcinoma is an indolent lesion (although the possibility of metastasis does exist).

You can learn more about tumors of the mammary gland from our series 5 fascicle (arppress.org/books/book/63)!

#BreastPath

arppress.org Tumors of the Mammary Gland

ARP Press Verified account @ARP_Press Oct 15

October is Breast Cancer Awareness Month, inspiring our case of the month:

A 70yoW presents with a single, lobulated, retroareolar breast mass. A-B H&Es, C P63, D SMM-HC

See the poll below - what's your diagnosis? Answer and discussion out in a couple of days!
#BreastPath

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ARP Press @ARP_Press Oct 15

October is Breast Cancer Awareness Month, inspiring our case of the month:

A 70yoW presents with a single, lobulated, retroareolar breast mass. A-B H&Es, C P63, D SMM-HC

See the poll below - what's your diagnosis? Answer and discussion out in a couple of days!
#BreastPath

ARP Press @ARP_Press Sep 27

We're re-visiting our series 5 fascicle, Tumors of the Eye and Ocular Adnexa (arppress.org/books/book/26)!
Sebaceous gland hyperplasia is common in the periocular tissues of older people due to the abundance of sebaceous glands, and consists of hypertrophic and hyperplastic, fully mature sebaceous gland lobules in a symmetric arrangement clustered around a central dilated sebaceous duct. The example here presented as a caruncular mass.
#OcularPath

SEBACEOUS GLAND HYPERPLASIA: CARUNCLE
Left: A yellow, lobulated, well-circumscribed caruncular mass. (Courtesy of Drs. J. Shields and C. Shields, Philadelphia, PA.)
Right: Hypertrophic and hyperplastic sebaceous gland lobules are arranged around a central dilated duct (arrowhead) (H&E stain).

ARP Press @ARP_Press Sep 21

Correct, this is small cell carcinoma, hypercalcemic type!
This is an undifferentiated ovarian tumor that occurs in young women and children that has a variable appearance composed of morphologically small cells, and is sometimes associated with hypercalcemia. SMARCA4/BRG1 IHC is a very helpful diagnostic marker; expression is lost in these tumors (image F).
#GynPath

SMALL CELL CARCINOMA OF THE OVARY, HYPERCALCEMIC TYPE

A: The tumor grows in a solid fashion with multiple pseudofollicles.

B: The tumor cells are small with minimal cytoplasm. Numerous mitoses are identified.

C,D: The pseudofollicles are lined by malignant cells, and are filled with an eosinophilic material.

E: This image highlights the large cell variant of small cell hypercalcemic type, and demonstrates the rhabdoid like appearance of the tumor cells.

F: Immunohistochemistry with BRG1 is diagnostic, with loss of this marker in the malignant cells (and retained staining in lymphocytes and other benign stromal cells).

ARP Press Verified account @ARP_Press Sep 16

What's your diagnosis?
GrCT = granulosa cell tumor; SmCC - small cell carcinoma SLCT = Sertoli-Leydig cell tumor
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