Transplantation and Cellular Therapy Journal

A major update from ASTCT! New consensus grading criteria refine CRS and ICANS assessments and address emerging toxicities following immune effector cell therapy, supporting standardized toxicity evaluation across clinical trials and practice. ow.ly/Wsig5103RX0

This propensity score-matched analysis found that single-dose high-dose melphalan reduced severe gastrointestinal, renal and hepatic toxicities compared with split-dose conditioning, with no differences in survival or Day +90 response rates. Read: ow.ly/k7jA5103RQZ

This critical review examines tools for predicting #CART toxicities, highlighting EASIX for severe CRS and ICANS and CAR-HEMATOTOX for prolonged cytopenia. Integrating clinical scores, CAR-T kinetics and imaging biomarkers may improve risk stratification. astctjournal.org/article/S2666-…

This study found that elevated plasma desmosine was associated with lung function decline and greater skin sclerosis severity in chronic #GVHD, highlighting its potential as a biomarker for pulmonary and cutaneous involvement. astctjournal.org/article/S2666-…

The October issue of 'Transplantation and Cellular Therapy,' is now available online: astctjournal.org/current