AggarwalLab

@AggarwalLab

Synthetic organic chemistry group focused on the incorporation, homologation and functionalisation of organoboron compounds. Group ran account.

Bristol, England chm.bris.ac.uk/org/aggarwal/i… Joined September 2018

191 Following 11K Followers 344 Posts

Latest posts 5

AggarwalLab @AggarwalLab Oct 25

Two distant stereocentres. One smooth catalytic cycle!

Our latest @JACS installs 1,6-stereocentres via Ir-cat asymmetric allylation of resorcinol boronate complex, enabling the total synthesis of merocyclophane A. Congrats, team!

🔗 doi.org/10.1021/jacs.6…

@BristolChem

pubs.acs.org Simultaneous Installation of 1,6-Stereocenters by Asymmetric Allylation of Resorcinol Boronates:... Abstract. Installing multiple noncontiguous stereocenters in a single catalytic event offers a powerful platform for constructing complex three-dimensional

AggarwalLab @AggarwalLab Oct 19

We say goodbye to Max Roth, our visiting Master’s student from RWTH Aachen University 🇩🇪

Wishing you all the best in your future endeavours, Max!

AggarwalLab @AggarwalLab Oct 5

Congrats to our very own Prof. Varinder Aggarwal who has been awarded the 2026 Nagoya Gold Medal Prize. This prize was established in 1995 by Prof. Noyori and is awarded to an organic chemist who has made significant original contributions to the field in its broadest sense.

AggarwalLab @AggarwalLab Oct 5

Think outside the box, but for stubborn thiazoles, think outside the ring!

Our latest @angew_chem, (in collab w/ @merckgroup) LiBAP cross-coupling, exploits an out-of-ring sulfinyl activation unlocking 1,2-migration that thiazoles resist.
onlinelibrary.wiley.com/doi/10.1002/an…
@BristolChem

onlinelibrary.wiley.com Aromatic Pummerer‐Promoted Stereospecific Cross‐Coupling of Thiazoles With Boronic Esters A lithiation–borylation–aromatic Pummerer (LiBAP) strategy enables stereospecific, C5-selective C(sp2)–C(sp3) cross-coupling of thiazoles with boronic esters. By using exocyclic sulfoxide activation...

AggarwalLab @AggarwalLab Sep 24

One catalyst, two geometries.

Check out the work from the Zheng and You group showing how Ir catalysis enables stereodivergent access to chiral Z- and E-allylated isochromanones.

Original article: cell.com/chem-catalysis…

Our Preview: doi.org/10.1016/j.chem…

www.cell.com Iridium-catalyzed asymmetric allylic substitution with 3-isochromanones enables selective access to... Olefin geometry profoundly dictates the properties of bioactive molecules, natural products, and organic materials. Herein, we describe a synthetic protocol enabling the selective construction of...