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@AgingBiology

Latest news in the biology and genetics of aging, covering longevity science, rejuvenation technologies and life-extension research. Tweets by @jpsenescence

senescence.info Joined November 2013

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Aging Science News @AgingBiology Jan 5, 2024

New description of the Human Ageing Genomic Resources (HAGR)

Since its inception 20 years ago, HAGR has become the leading online platform in ageing research.

A brief thread on HAGR's databases 🧵
academic.oup.com/nar/article/52…

academic.oup.com Human Ageing Genomic Resources: updates on key databases in ageing research Abstract. Ageing is a complex and multifactorial process. For two decades, the Human Ageing Genomic Resources (HAGR) have aided researchers in the study of

Aging Science News @AgingBiology 2h

Small extracellular vesicles as mediators of paracrine senescence in cellular models of aging
aging-us.com/article/206425…

www.aging-us.com Small extracellular vesicles as mediators of paracrine senescence in cellular models of aging |... Senescent cells accumulate during both physiological and pathological processes, including aging. They are characterized by the expression of the cell cycle inhibitor p16INK4A and the senescence-asso

Aging Science News @AgingBiology 10h

Long-Term Post-Mitotic Culture of Human Fibroblasts Recapitulates and Accelerates Features of In Vivo Aging and Enables Dynamic Testing of Anti-Aging Compounds
onlinelibrary.wiley.com/doi/full/10.11…

onlinelibrary.wiley.com Long‐Term Post‐Mitotic Culture of Human Fibroblasts Recapitulates and Accelerates Features of... Human fibroblasts undergo accelerated molecular aging in long-term culture, recapitulating in-vivo aging signatures and increasing age-related heterogeneity. Direct neuronal conversion preserves...

Aging Science News @AgingBiology 13h

Cutting time short or long? Castration, developmental timing, and longevity in imperial China
tandfonline.com/doi/full/10.10…

www.tandfonline.com Cutting time short or long? Castration, developmental timing, and longevity in imperial China Life-history theory predicts a trade-off between reproduction and longevity. Castration has been proposed to extend male lifespan by reducing androgen-related costs, but evidence from human populat...

Aging Science News @AgingBiology 14h

Artificial Intelligence in Longevity Research: From Molecular Clocks to Interventional Geroscience
preprints.org/manuscript/202…

www.preprints.org Artificial Intelligence in Longevity Research: From Molecular Clocks to Interventional Geroscience Artificial intelligence (AI) has expanded the scale, resolution, and modalities through which biological aging can be estimated, but evidence that these estimates are valid intervention targets or...