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We are delighted to share our new work as a preprint on medRxiv, examining hematopoietic aging in type 1 diabetes (T1D).
Analyzing data from >416,000 UK Biobank participants, we show that T1D is associated with accelerated hematopoietic aging, including earlier clonal hematopoiesis (CHIP) and disease-accelerated telomere attrition. Interestingly, telomere attrition—but not CHIP—was associated with myocardial infarction risk in T1D.
By integrating epidemiology, human genetics, Mendelian randomization, and single-cell regulatory genomics, our work identifies telomere biology as a potential contributor to excess cardiovascular risk in T1D.
This work was led by the incredibly talented Ziang Xu, who will join the University of Pennsylvania this summer for a PhD in Genomics & Computational Biology.
Congratulations as well to co-author Sourav Roy, who will also join the Duke University MD/PhD this summer.
We are very proud of them and excited to see them take this next step in their scientific journeys.
Accelerated hematopoietic aging in type 1 diabetes links telomere attrition to myocardial infarction medrxiv.org/content/10.648…
Analyzing data from >416,000 UK Biobank participants, we show that T1D is associated with accelerated hematopoietic aging, including earlier clonal hematopoiesis (CHIP) and disease-accelerated telomere attrition. Interestingly, telomere attrition—but not CHIP—was associated with myocardial infarction risk in T1D.
By integrating epidemiology, human genetics, Mendelian randomization, and single-cell regulatory genomics, our work identifies telomere biology as a potential contributor to excess cardiovascular risk in T1D.
This work was led by the incredibly talented Ziang Xu, who will join the University of Pennsylvania this summer for a PhD in Genomics & Computational Biology.
Congratulations as well to co-author Sourav Roy, who will also join the Duke University MD/PhD this summer.
We are very proud of them and excited to see them take this next step in their scientific journeys.
Accelerated hematopoietic aging in type 1 diabetes links telomere attrition to myocardial infarction medrxiv.org/content/10.648…
www.medrxiv.org Accelerated hematopoietic aging in type 1 diabetes links telomere attrition to myocardial infarction Type 1 diabetes (T1D) is associated with early-onset and increased risk of coronary artery disease (CAD), particularly myocardial infarction (MI), that is not fully explained by traditional cardiov... 
