ALife Papers

@AlifePapers

Artificial Life papers. Accepting recommendations! Picture: Machina Docilis by G. Walter.
By @sina_lana @moreau_austin @ISALstudents @caranha

Joined October 2018

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ALife Papers @AlifePapers Jul 31, 2019

**admin**

I am very honored to receive the ISAL @alifeofficial Education and Outreach Award for creating and curating this account.
Please consider sending your papers this way: tweets receive on average 3,000 views and up to 30,000 views for the most popular ones!

ALife Papers @AlifePapers Jan 25, 2023

newatlas.com/biology/semi-l…

newatlas.com Semi-living "cyborg cells" can survive where normal bacteria can't Manipulating microbes to work for us has been a staple of human civilization for millennia, since we learned how to use yeast to make bread and booze. In a modern breakthrough, scientists have now...

ALife Papers @AlifePapers Nov 7, 2022

Fundamental behaviors emerge from simulations of a living minimal cell

We present a whole-cell fully dynamical kinetic model (WCM) of JCVI-syn3A, a minimal cell with a reduced genome of 493 genes that has retained few regulatory proteins or small RNAs.

cell.com/cell/fulltext/…

Summary
We present a whole-cell fully dynamical kinetic model (WCM) of JCVI-syn3A, a minimal cell with a reduced genome of 493 genes that has retained few regulatory proteins or small RNAs. Cryo-electron tomograms provide the cell geometry and ribosome distributions. Time-dependent behaviors of concentrations and reaction fluxes from stochastic-deterministic simulations over a cell cycle reveal how the cell balances demands of its metabolism, genetic information processes, and growth, and offer insight into the principles of life for this minimal cell. The energy economy of each process including active transport of amino acids, nucleosides, and ions is analyzed. WCM reveals how emergent imbalances lead to slowdowns in the rates of transcription and translation. Integration of experimental data is critical in building a kinetic model from which emerges a genome-wide distribution of mRNA half-lives, multiple DNA replication events that can be compared to qPCR results, and the experiment

Highlights
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3D spatial resolution of a fully dynamical whole-cell kinetic model
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Detailed single-reaction, single-cell accounting of time-dependent ATP costs
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Genome-wide mRNA half-lives emerge from length-dependent kinetics and diffusion
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Connections among metabolism, genetic information, and cell growth are revealed

ALife Papers @AlifePapers Oct 6, 2022

scitechdaily.com/the-fountain-o…

ALife Papers @AlifePapers Aug 21, 2022

phys.org/news/2022-08-b…

phys.org Why are bigger animals more energy-efficient? A new answer to a centuries-old biological puzzle If you think about "unraveling the mysteries of the universe," you probably think of physics: astronomers peering through telescopes at distant galaxies, or experimenters smashing particles to...