The Arany lab

@AranyLab

We are the Arany lab at University of Pennsylvania. We love metabolism !

University of Pennsylvania med.upenn.edu/aranylab/ Joined December 2019

186 Following 1.4K Followers 237 Posts

Latest posts 5

The Arany lab @AranyLab Oct 15, 2024

Reporting with pride: (1) our star Jessie Axsom is now Dr.! (2) her paper is out @Cell_Metabolism: unbelievably comprehensive quantification of fuel fluxes in #exercise mice - lots of surprises. #MoTrPAC: take note. w/Rabinowitz lab. Free link 50days: authors.elsevier.com/a/1jxL75WXUlWk…

The Arany lab @AranyLab Aug 4, 2024

Fantastic brief historical overview of mechanism behind #preeclampsia from brilliant friend @ananthmsn34 in @jclinicalinvest : jci.org/articles/view/…

The Arany lab @AranyLab Jul 27, 2024

We think this one is groundbreaking: Do you wonder how #SGLT2 inhibitors protect from heart failure? We show that #empagliflozen directly activates PANK1, rate-limiting for CoA synthesis, in human hearts. You read it here first! biorxiv.org/content/10.110…

www.biorxiv.org SGLT2 inhibitors activate pantothenate kinase in the human heart Inhibitors of sodium glucose cotransporter-2 (SGLT2i) demonstrate strong symptomatic and mortality benefits in the treatment of heart failure but appear to do so independently of SGLT2. The relevant...

The Arany lab @AranyLab Jul 25, 2024

it's been a while since we posted... Here our recent review w/ @Rongtian2 on HUMAN cardiac metabolism in @Cell_Metabolism : deep dive going back 50+yrs - turned out to be >300 refs! Much is known, much MORE needs figured out... cell.com/cell-metabolis…

The Arany lab @AranyLab Jul 25, 2024

Translating metabolic and cardiovascular research into effective treatments: What’s next? Some thoughts from several of us on the topic, in this issue of Cell: authors.elsevier.com/a/1jUX4L7PXqREY
@JuleenRZierath @JolandavanderV4 @Alicardsdoc @rosenzweig_a @DebMuoio