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Adam Gayoso Verified account @adamgayoso · 3d

Single-cell atlases continue to map the diversity of cell states, but how can we use them to interpret non-coding genetic variants?

Excited to share AlphaGenome 2, our model for predicting cell-type-specific regulatory activity and variant effects from DNA sequence.

deepmind.google/blog/alphageno…

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Pushmeet Kohli Verified account @pushmeet · Oct 7

Building predictive biology models is one of the most important scientific challenges of our time, but solving this requires new experimental biological data at an unprecedented scale.

I’m pleased to announce that @GoogleDeepmind is partnering with @ChanZuckerberg’s Virtual Biology Initiative to create the multi-modal datasets needed for improved predictive biology models.

I wrote recently about the need to discover how life works at many different scales, from DNA and individual proteins to living cells and whole-body health. As we learnt from AlphaFold and the Protein Data Bank, solving grand biological challenges will not be possible without high-quality open data and efforts like the @czbiohub initiative.

Read the announcement here: biohub.org/news/virtual-b…

And my previous essay here: linkedin.com/pulse/understa…

@AllenInstitute, @BroadInstitute, @GladstoneInst, @humancellatlas, @ProteinAtlas, @sangerinstitute, @IsomorphicLabs, @Meta

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