Proud to have been part of this important practice defining trial. @bhaffty @RutgersCancer @RU_RadOnc
VIDEO: PMRT with breast reconstruction — 16 fractions instead of 25? RT CHARM (JCO, Oct 12, 2026): 24-mo reconstruction complications 12.3% vs 10.2%, noninferior ☢️🎗️
👉 oncologytube.com/pmrt-rt-charm-…
🔹 Phase 3 Alliance A221505: 898 enrolled, 825 evaluable; 42.56 Gy/16 fx (~3 wk) vs 50 Gy/25 fx (5 wk)
🔹 Difference −2.1% (95% CI −6.5 to 2.2), within the 10% noninferiority margin; 36-mo LRR 1.5% vs 2.2%
🔹 Acute/late toxicity not different; implant-only reconstruction had more complications in both arms (OR 1.65)
Noninferior is not fewer complications: the 16-fraction rate was numerically higher, which belongs in the implant conversation.
@theRADSofKHAN @BHaffty @huntsmancancer @reshmajagsi @CShahMD @RTendulkarMD @ErinGillespieMD @RachelJimenezMD @KimCorbinMD @George_E_Naoum @shanestecklein @fumikochino @KHoffmanMD @NeilTaunkMD @DashaKlebaner @Sushilberiwal @5_utr @RadiantRehemaMD @JKocsisMD @drshuja3 @DrJudyBoughey @TariKingMD @kpmcguiremd @DrNimmiKapoor @DrSummerHanson @DrChrisHomsy @WilmotCancer @tmprowell @to_be_elizabeth @Monthy_A @MeritxellMolla @KefahMokbel @RICKLIN4TH @rrpaulinelli @drluismorenos
#bcsm #radonc #PMRT #breastcancer #breastreconstruction #hypofractionationView quoted post on X
