Bashor Lab

@BashorLab

Bashor Lab in Houston, Texas | Mammalian Synthetic Biology et al.

Houston, TX bashorlab.rice.edu Joined December 2022

815 Following 1K Followers 236 Posts

Latest posts 5

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Bashor Lab @BashorLab Feb 26

We are pleased to share a paper from our lab out in this week’s issue of @Nature, where we show that HT + ML can dramatically speed up the synbio DBTL cycles, profiling gene circuit design spaces at unprecedented scale: nature.com/articles/s4158… (1/16)

www.nature.com Ultra-high-throughput mapping of genetic design space Nature - CLASSIC is a high-throughput genetic profiling platform that combines long- and short-read next-generation-sequencing modalities to quantitatively assess pools of constructs of arbitrary...

Bashor Lab @BashorLab Sep 24

Beautiful work from Ron Weiss and team - a significant step forward for ML-driven design of synthetic circuits. biorxiv.org/content/10.648…

www.biorxiv.org Generative Neuromorphic Programming of Mammalian Cells Cells make decisions through densely interconnected regulatory networks that compute graded, analog responses[[1][1], [2][2]]. Synthetic biology has made cells programmable, but the field’s dominant...

Bashor Lab @BashorLab May 31

Programmable DNA integration with New-to-Nature tools using Computational Protein Design biorxiv.org/content/10.648…

Bashor Lab @BashorLab Apr 30

Gene syntax defines supercoiling-mediated transcriptional feedback | Science science.org/doi/10.1126/sc…

www.science.org Gene syntax defines supercoiling-mediated transcriptional feedback Gene syntax—the order and arrangement of genes and their regulatory elements—shapes the dynamic coordination of both natural and synthetic gene circuits. Transcription at one locus perturbs the...

Bashor Lab @BashorLab Jan 22

Mammalian genome writing: Unlocking new length scales for genome engin... sciencedirect.com/science/articl…