Basler Lab

Congrats to @JennyferTrouve and Aljoscha for developing LiFEx (Live-to-Fixed Expansion microscopy)! It enables correlating live-cell imaging with high-resolution cellular ultrastructure to track Burkholderia T6SS assembly and downstream membrane rupture:
biorxiv.org/content/10.648…

Congrats to @ATejadaArranz & the team for showing that Pseudomonas forms distinct subpopulations during infection, each damaging host tissue by a different mechanism.
Toolbox: single-cell microscopy, 3D image segmentation, high-sensitivity mass spec:
doi.org/10.64898/2026.…

When Pseudomonas is attacked, it strikes back!
Outer membrane damage triggers a tit-for-tat T6SS retaliation via TagQ/TagR protein complex assembly, activating the PpkA kinase.
Congrats to Maxim & team for uncovering this fascinating mechanism!
nature.com/articles/s4146…

In our new paper, we uncover how Burkholderia switches from antibacterial T6SS-1 to eukaryotic-targeting T6SS-5. Surprisingly, actively turning off T6SS-1 assembly prevents mitochondrial damage and apoptosis.

Congrats @christy_chc and the team!

link.springer.com/article/10.103…

Interested in the Function and Regulation of #T6SS? Do you have relevant experience from your Master's project? Apply to this PhD position in our lab:
biozentrum.unibas.ch/open-positions…