Ben Lehner
@BenLehner
Head of Generative Genomics @sangerinstitute;
Systems + Synthetic Biology @CRGenomica;
Co-founder allox.bio barcelonacollaboratorium.com
Systems + Synthetic Biology @CRGenomica;
Co-founder allox.bio barcelonacollaboratorium.com
4.1K Following 5.5K Followers 2.6K Posts
Latest posts 5
Conservation and divergence in the allosteric architectures of five human protein kinases. Excited to share our new preprint by @Carlafolgado + @mutatoni @sangerinstitute @CRGenomica @IBV_CSIC
biorxiv.org/content/10.648…
biorxiv.org/content/10.648…
www.biorxiv.org Conservation and divergence in the allosteric architectures of five human protein kinases Protein kinases are central to biological regulation, dysregulated in many diseases, and the targets of a hundred clinically-approved drugs. Structural conservation of kinase active sites makes the... Allostery is a widespread cause of loss-of-function variant pathogenicity by @liao_xiaotian @sangerinstitute nature.com/articles/s4146…
www.nature.com Allostery is a widespread cause of loss-of-function variant pathogenicity Nature Communications - Mutations at sites distant from a protein’s active site can disrupt function through allosteric mechanisms. Here, authors present evidence that allostery is a... Complete Mutagenesis of the Genome and Proteome of ΦX174. 1st genome sequenced (Sanger 1977), 1st genome
synthesised (Venter 2003), first genome + proteome fully mutated (@huijin6418 and @XianghuaLi2 2026) @CRGenomica @sangerinstitute
biorxiv.org/content/10.648…
synthesised (Venter 2003), first genome + proteome fully mutated (@huijin6418 and @XianghuaLi2 2026) @CRGenomica @sangerinstitute
biorxiv.org/content/10.648…
www.biorxiv.org Complete Mutagenesis of the Genome and Proteome of ΦX174 The bacteriophage ΦX174 was the first genome to be sequenced and the first to be chemically synthesised. Here we present a complete map of the consequences of changing every nucleotide in the ΦX174... Excited to announce #OpenSplice
@gioia_40ni quantified the impact of >500,000
mutations on the alternative splicing of 600 human exons
biorxiv.org/content/10.648…
results.hgi.sanger.ac.uk/OpenSplice/
@OpenTargets @sangerinstitute @CRGenomica
#cshlsymp26 #RNA2026 @RNASociety
@gioia_40ni quantified the impact of >500,000
mutations on the alternative splicing of 600 human exons
biorxiv.org/content/10.648…
results.hgi.sanger.ac.uk/OpenSplice/
@OpenTargets @sangerinstitute @CRGenomica
#cshlsymp26 #RNA2026 @RNASociety