Bernards Laboratory@NKI
@BernardsLabora1
We develop novel therapeutic stategies for cancer
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Very honored by the recognition by my British colleagues. royalsociety.org/news/2024/05/n…
Very grateful to the ERC for granting the lab a third ERC advanced grant. With this new funding, we will study further the concept of deliberate overactivation of oncogenic signaling as a cancer treatment strategy.
We discovered a major role for PP2A in controlling splicing, suggesting that PP2A inhibition sensitizes to checkpoint immunotherapy by generating neo antigens.
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
www.biorxiv.org PP2A inhibition instructs spliceosome phosphorylation to create splicing vulnerability in colon... Protein phosphatase 2A (PP2A) is a versatile enzyme affecting many aspects of cellular physiology. However, it remains unclear which of the cellular processes are most perturbed upon PP2A inhibition...