Pinned post
Thrilled to share our latest study to understand the genomic and epigenetic roles of TDP-43 in regulating local gene expression, long range promoter-enhancer interaction and transposable elements expression via R-loop and 5hmC crosstalk.
cell.com/cell-reports/f…
cell.com/cell-reports/f…
www.cell.com TDP-43 chronic deficiency leads to dysregulation of transposable elements and gene expression by... Hou et al. report that TDP-43 chronic deficiency alters R-loops and 5hmC at genic regions, enhancers, and transposable element loci to dysregulate critical gene and transposable element expression.... 
