Boyang Fu

This account is verified. Learn more

@Boyang1995

Postdoc @Harvard with @marinkazitnik | Ph.D. @UCLA with @sr_sankararaman | Ex-AI Resident @Google-X

Boston, MA fboyang.github.io Joined November 2016

452 Following 337 Followers 150 Posts

Latest posts 5

Pinned post

Boyang Fu @Boyang1995 Dec 9, 2025

🧬 Do genetic variants interact in humans?

For years, the answer was “probably, but we lacked solid statistical evidence.” We now bring one of the strongest pieces of evidence to date.

Thrilled to share our latest work, FAME, now at Nature Genetics: nature.com/articles/s4158…

www.nature.com A biobank-scale test of marginal epistasis reveals genome-wide signals of polygenic interaction... Nature Genetics - FAME is a biobank-scale method that tests whether the effect of an SNP on a quantitative trait is modulated by an individual’s polygenic background. FAME can also be used to...

Boyang Fu @Boyang1995 Oct 24

How do cells respond to perturbations in concert with their neighbors? Excited to have played a part in CONCERT! 🎻

Marinka Zitnik Verified account @marinkazitnik Oct 24

When you knock out a gene in a tissue, the effect starts in the perturbed cells and extends into their neighborhood. The same knockout can produce one response in a tumor core and another at a tissue border

CONCERT is a generative model that predicts how perturbation effects propagate across tissue

biorxiv.org/content/10.110…

Cells in a tissue act in concert, and CONCERT predicts how the whole ensemble responds when one player changes its part 🧵

View quoted post on X

Boyang Fu @Boyang1995 Sep 10

When I first read GPN in 2023 PNAS, I thought it was a beautiful idea, struck by its 2 rejections and 4 review rounds. Seeing GPN-Star in Nature is incredibly inspiring. A humbling reminder that great ideas aren’t always recognized at first. Persistence matters.

Yun S. Song @yun_s_song Sep 9

We are thrilled to share that our GPN-Star manuscript is now published and freely available:
doi.org/10.1038/s41586…
(1/n)
View quoted post on X

Boyang Fu @Boyang1995 Aug 20

Timely report. A good reminder to rethink how we evaluate virtual cell models. DE-based metrics remain widely used in perturbation benchmarks, often without sufficient attention to how the underlying DE is defined and calculated.

Jingyi Jessica Li (李婧翌) @jsb_ucla Aug 19

1/5 New in Cell Systems: our commentary revisits a recent Nature debate over memory-associated gene-expression changes in single-cell data.

The debate centered on whether reported differential-expression (DE) signals were statistically reliable.
View quoted post on X

Boyang Fu @Boyang1995 Aug 15

Fully agree that restricted AI ecosystems disadvantage academic labs in defensive tools.

We need an open-source biosecurity policy shaped by multi-stakeholder consensus with domain researchers, not unilateral platform restrictions.

Brian Hie Verified account @BrianHie Aug 15

Following the publication of our phage gen paper, I wrote some personal thoughts on biosafety and biosecurity as generative biology improves.

Given the trajectory of progress, there should be concern and urgency -- but also optimism.

brianhie.com/present_and_fu…
View quoted post on X