Jon Brestoff

@BrestoffLab

Associate Professor MD/PhD @WashuMedicine studying #immunometabolism and #mitochondria transfer in metabolic diseases like #obesity #diabetes and #LeighSyndrome

St Louis, MO brestofflab.com Joined July 2019

471 Following 1.5K Followers 555 Posts

Latest posts 5

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Jon Brestoff @BrestoffLab Nov 8, 2023

Curious about #mitochondria transfer?

Check out our latest #MitoTransfer review with the @theHumanBorch in @Nature

Feel free to post your thoughts, ideas, and questions below. Please RT to help grow this blossoming field.

nature.com/articles/s4158…

www.nature.com The power and potential of mitochondria transfer Nature - The mechanisms by which mitochondria are transferred between cells and how intercellular mitochondria transfer regulates physiological processes and disease pathogenesis are discussed.

Jon Brestoff @BrestoffLab Apr 17

Exciting new paper on #MitoCatch to target mitochondria transplants to cells of interest, rescuing neurons in #LHON

Check out our News & Views in @Nature for a synopsis and big questions for the field:

nature.com/articles/d4158…

@washu_pathology @washumedicine @Samanthakrysa

www.nature.com Therapeutic mitochondria transplants made more efficient with targeting tool Nature - A system of protein binders directs energy-generating organelles to targeted cells, potentially improving ways to treat mitochondrial dysfunction.

Jon Brestoff @BrestoffLab Dec 31, 2025

This was a fun surprise today! #1 cited review in @NatMetabolism in 2025.

Nature Metabolism Verified account @NatMetabolism Dec 31, 2025

Reviews/Perspectives Top #Citations 2025: 🥇

Jonathan Brestoff (@BrestoffLab, @WashUDeptMed), Keshav Singh (@mitoscientist, @UABHeersink) et al.

Recommendations for mitochondria transfer and transplantation nomenclature and characterization

nature.com/articles/s4225…
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Jon Brestoff @BrestoffLab Dec 15, 2025

Steven L Teitelbaum, MD, a legend @washumedicine, passed away.

He was a rigorous physician-scientist, life altering mentor, fierce advocate, and family man. I feel lucky to have gotten to work so closely with him. Few have taught me as much as he did.

Jon Brestoff @BrestoffLab Dec 12, 2025

Proud to announce Dr Stella Varnum!

Her defense today was flawless. She is the first PhD student to graduate from my lab, so it was extra bittersweet today. #proudPI @WUSTLImmuno