Fun collaboration w/@HornbergerLab!
Many questions remain, but 2 stand out:
1) How does muscle determine which myofibrils to remove during atrophy?
2) Why are myofibrils lost primarily from SERCA1+ fibers, but SERCA2+ fibers are largely preserved?
physoc.onlinelibrary.wiley.com/doi/10.1113/JP…
Many questions remain, but 2 stand out:
1) How does muscle determine which myofibrils to remove during atrophy?
2) Why are myofibrils lost primarily from SERCA1+ fibers, but SERCA2+ fibers are largely preserved?
physoc.onlinelibrary.wiley.com/doi/10.1113/JP…
physoc.onlinelibrary.wiley.com Macroscopic to ultrastructural analyses identify the loss of myofibrils as the primary mediator of... Abstract figure legend Skeletal muscle structure was analysed at three levels in young vs. aged humans, and in young vs. aged mice subjected to unilateral hindlimb immobilization to model disuse.... 
