Leandro Slipczuk

Lp(a)HORIZON was negative. But what exactly did it disprove?

Not that Lp(a) is causal.
Not that we can lower it.
It challenged whether pharmacologic lowering reduces events.
The full data with component outcomes, precision, subgroup analyses, and timing will determine what comes next.

New viewpoint in @PCVDJournal

@AbdelazizMD1 @DLBHATTMD @ElsevierConnect

sciencedirect.com/science/articl…

In >73,000 patients undergoing SPECT/PET MPI across 20 sites, ischemia remained prognostic across age groups and generally identified patients with better outcomes after early revascularization. The association was less clear in those ≥85. PET myocardial flow reserve may add useful physiologic information in older adults. @Piotr_JSlomka @krishnapatel888

Beyond stenosis: imaging phenotyping and risk stratification in nonobstructive coronary artery disease
shorturl.at/fI2bu

@pamelapina_s @AnnalisaFiltz @danilorenzatti @Ankurdee1 @JaideepBha35378 @Piotr_JSlomka @danielbermanmd @damini_dey

@MonteHeart @MontefioreNYC @EinsteinMed

South Asian Cardiovascular Risk: Role of Coronary Artery Calcium Scoring and Computed Tomography Angiography. Outstanding work led by @DineshKalra and @virani_md just published in @JACCJournals

jacc.org/doi/10.1016/j.…

@MontefioreNYC @MonteHeart @EinsteinMed

Happy to share our editorial, "Another Win for Lifestyle Medicine: Cardiac Rehabilitation–Based Therapy for ANOCA," published in JACC: Cardiovascular Interventions alongside the important SAMCRO randomized trial.

Despite the absence of obstructive coronary artery disease, patients with angina and no obstructive coronary arteries (ANOCA) often experience persistent symptoms, impaired quality of life, repeated testing, and uncertainty regarding their diagnosis. The challenge is no longer simply recognizing ANOCA but delivering effective, comprehensive treatment.

Congratulations to the investigators for advancing the field with high-quality randomized evidence, and to my co-authors Chip Lavie and Fabian Sanchis-Gomar for the opportunity to collaborate on this editorial.

Editorial: authors.elsevier.com/a/1nVvY6uPJw09…
Original research: sciencedirect.com/science/articl…

@CarlLavie31733 @MonteHeart @JACCJournals @ElsevierConnect