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Choudhary Lab CPR

@ChoudharyLabCPR

Lab twitter account for Chuna Choudhary lab at NNF-CPR in Copenhagen
Joined March 2021
86 Following 506 Followers 93 Posts

Latest posts 5

Choudhary Lab CPR @ChoudharyLabCPR
Cohesin and CTCF jointly fold genomes, but why do their depletion affect few genes, with minimal overlap? Do all regulated genes require looping and enhancers? In our new paper in Nature Genetics we disentangle their functions in gene regulation.
nature.com/articles/s4158…
www.nature.com Disentangling the architectural and non-architectural functions of CTCF and cohesin in gene... Nature Genetics - This study provides insights into the chromatin-looping-dependent and chromatin-looping-independent roles of cohesin and CTCF in controlling gene regulation.
Choudhary Lab CPR @ChoudharyLabCPR
Do enhancers often skip active genes? Our other recent preprint revises current models, that enhancers frequently and by design skip active genes to activate distal targets. Instead simple rules can predict enhancer and GWAS targets. biorxiv.org/content/10.110…
www.biorxiv.org Mammalian enhancers and GWASs act proximally and seldom skip active genes Enhancers play a critical role in regulating transcription. Nearly 90% of human genetic variants identified in genome-wide association studies (GWAS) are located in distal regions, underscoring the...
1 replies 16 reposts 82 likes 8.8K views View on X
Choudhary Lab CPR @ChoudharyLabCPR
How do cohesin and CTCF control gene expression and what are their links to enhancers? Our new preprint unravels their shared and unique roles: from precise enhancer targeting to direct transcriptional activator functions of CTCF.
#Genomics #CTCF #Cohesin
biorxiv.org/content/10.110…
www.biorxiv.org A unified model of gene expression control by cohesin and CTCF Cohesin and CTCF fold vertebrate genomes into loops and topologically associating domains (TADs). The genome folding by cohesin and CTCF is considered crucial for enhancer-promoter communication and...
1 replies 13 reposts 59 likes 6.2K views View on X
Choudhary Lab CPR @ChoudharyLabCPR
Is acetylation of proteins (and histones in particular) a cause or a consequence of gene transcription? We undertook an unbiased proteome-wide analysis of acetylation changes upon transcription inhibition and our results were just published nature.com/articles/s4146…
www.nature.com Acetylation of histones and non-histone proteins is not a mere consequence of ongoing transcription Nature Communications - Acetylation of histone lysine residues correlates with transcription activation, but it is currently debated whether histone acetylation is a cause or a consequence of...
3 replies 62 reposts 247 likes 32K views View on X
Choudhary Lab CPR @ChoudharyLabCPR
Great to see the published version of our paper characterizing the systems-scale stoichiometry and turnover of ubiquitylation out in @CellCellPress
cell.com/cell/fulltext/…
www.cell.com Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems... The occupancy of ubiquitylation sites is very low and inherently constrained by the amount of ubiquitin molecules, resulting in an ubiquitylation system that operates with the principle of low...