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Chris am Ende

@ChrisamEnde1

Organic chemist @Pfizer All opinions, posts/RTs are my own. #pfizercolleague
Connecticut, USA Joined December 2020
168 Following 224 Followers 146 Posts

Latest posts 5

Chris am Ende @ChrisamEnde1
A huge congrats to Joe! As my undergrad orgo prof, Joe inspired me to become a synthetic chemist. At Pfizer and in collaboration w/@FoxGroupUD, I am continually inspired by the impact his lab is making. Thank you, Joe, for being an amazing teacher, researcher, leader, and friend!
I could not have a better colleague than Joe Fox. Congrats ⁦@FoxGroupUD⁩ !! udel.edu/udaily/2023/no…
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Chris am Ende @ChrisamEnde1
Congrats @TallonAmanda on an exciting addition to the covalent reversible electophiles for #chemicalbiology and an amazing ongoing collaboration with @FoxGroupUD. We are already exploring these #tetrazines in multiple applications, so stay tuned!
Now out in @J_A_C_S a #ChemCollabs between #PfizerChemistry and the @FoxGroupUD exploring thio-tetrazines as reversible covalent inhibitors with switchable reactivity
doi.org/10.1021/jacs.3…
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Chris am Ende @ChrisamEnde1
Check out these reversible covalent warheads that can be switched off! Another great paper from a collaboration with the @FoxGroupUD and led by superstar grad student @TallonAmanda #collaboration #pfecolleague
Thiomethyltetrazines are reversible covalent cysteine warheads whose reversibility can be "switched off” via live cell bioorthogonal chem, providing stability to lysis/proteomics. Led by @TallonAmanda w/ @Pfizer Mary Xu, Graham West & @ChrisamEnde1 10.26434/chemrxiv-2023-w0p5m
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Chris am Ende @ChrisamEnde1
Check out this @J_A_C_S from @RosenbergerJE and @FoxGroupUD! #bioorthogonal chemistry for the win!
Out in @J_A_C_S! Ligand-directed catalysts for live-cell, photocatalytic activation of dihydrotetrazines coupled to new uncaging chemistry. Congratulations to Jules @RosenbergerJE, Yixin, Fang, Xinyi, Will and Olga! Thanks for support from NIGMS and
@Pfizer #PfizerChemistry
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Chris am Ende @ChrisamEnde1
Excited to see this in print! We love collaborating with @ballnchemist @theballlab. #PFEcolleague
Nicholas Ball @ballnchemist Jan 20, 2023
Curious about making S(VI)-fluorides and how they have been used in medicinal and biomolecular chemistry? Check out our latest review in @OrgBiomolChem. A collaboration between @ChrisamEnde1 and co at Pfizer and @theballlab!

pubs.rsc.org/en/content/art…

@pomonacollege @pfizer
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