Confinement Mechanobiology Lab at MBI

@ConfinementLab

We are the Confinement Mechanobiology Lab at @NUSingapore and @MBIsg. PI @ahcells, tweets by a rotating cast of group members

Singapore mbi.nus.edu.sg/andrew-holle/ Joined January 2022

61 Following 652 Followers 82 Posts

Latest posts 5

Confinement Mechanobiology Lab at MBI @ConfinementLab Jun 24, 2025

Join us at @MBIsg!

Andrew Holle @ahcells Jun 24, 2025

Interested in a #postdoc on nuclear #mechanobiology? We have a fully funded position in the @ConfinementLab designed to help you meet your career goals while researching the rapidly growing field of cellular #confinement. Please get in touch for more info!

View quoted post on X

Confinement Mechanobiology Lab at MBI @ConfinementLab May 27, 2025

Very cool finding🧩: It doesn’t matter if a cancer cell is more or less deformable, it still makes similar choices when navigating #confinement. @gijsjekoenderi1 team shows that “squeezability” alone doesn’t explain how cells pick their path!

Confinement Mechanobiology Lab at MBI @ConfinementLab Apr 14, 2025

How do cells 'feel' confinement? New research reveals how mechanical confinement compresses the #nucleus, triggering immobile cells to spread and migrate. -YJ sciencedirect.com/science/articl…

Confinement Mechanobiology Lab at MBI @ConfinementLab Mar 31, 2025

Surprise! 🤯Acute #chromatin decompaction stiffens nuclei (not softens!) via swelling & #lamin changes. Nanopillars reveal this time-dependent effect. Metastatic cells dodge stiffening by compacting chromatin—key for #confinedmigration. -NL biorxiv.org/content/10.110…

Confinement Mechanobiology Lab at MBI @ConfinementLab Mar 27, 2025

Fascinating in vivo tracking of collective cell migration under confinement @PNASNews! Reveals self-organized antiparallel streams and compressive ECM deformation. Now wondering: How do single cells navigate these complex microenvironments? 🤔 -LY
www-pnas-org.libproxy1.nus.edu.sg/doi/10.1073/pn…