Tim Craggs - Exciting CEO

@Craggs_Lab

PI @sheffielduni, Single-molecules, #FRET, #openScience, #openMicroscopy, #founder and #CEO @EI_Science “collision of science and religion”

Sheffield, England craggs-lab.com Joined May 2017

1.6K Following 3.1K Followers 8.1K Posts

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Tim Craggs - Exciting CEO @Craggs_Lab Nov 6, 2020

Build your own smfBox - everything you need to build and run accurate and dynamic smFRET experiments - cheaply! #openAccess #openSource #openMicroscopy Paper here:

rdcu.be/b9Prx

And a great intro video here from the master of microscopy nightmares @DrLachie. Enjoy!

2:05

Tim Craggs - Exciting CEO @Craggs_Lab Oct 2

How does a repair enzyme find one damaged spot among 3 billion base pairs?

Just published in Nucleic Acids Research:

we show that DNA damage itself reshapes the double helix, well beyond the lesion. A non-protein start to damage detection?

1/5

doi.org/10.1093/nar/gk…

Tim Craggs - Exciting CEO @Craggs_Lab Jan 7

Looking forward to a busy week!

Exciting Instruments Verified account @EI_science Jan 7

🇺🇸 This time next week, we'll be midway through a trip to beautiful San Francisco to meet with investors and customers.

If you’ll be in the area and would like to catch up while we’re there, we’d love to connect to discuss the impact of in-solution single-molecule techniques for academia and industry, as well as our Exciting plans for 2026.

Just reply to this post or contact us at info@excitinginstruments.com.

We're around Monday through Thursday. Hope to see you there!

#startups #sanfrancisco #singlemolecule #smFRET #FCS #FCCS

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Tim Craggs - Exciting CEO @Craggs_Lab Sep 28, 2025

This is next level protein design! Absolute genius.

Would love to look at the induced conformational change using single-molecule FRET.

Adam Broerman @adam_broerman Sep 24, 2025

We sought to make proteins both potent and FAST. We used #proteindesign to design precise control over protein interaction lifetimes, enabling us to construct rapid-response circuits, biosensors, and switchable cytokines. Now published @Nature! Links to paper and tutorial below.

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Tim Craggs - Exciting CEO @Craggs_Lab Aug 2, 2025

This is really useful work - great labelling strategy for tricky nucleic acids. Also - loving the emoji 🧬🟢🔴

Chris H. Hill @chillzaa Jul 30, 2025

Ever struggled with low PNK efficiency on a structured piece of RNA? Sarah solved this problem by using a DNA scaffold to make the 5' end more accessible, improving the efficiency of end labelling. This enabled us to make smFRET measurements on the SARS-CoV-2 pseudoknot 🧬🔴🟢
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