Drug Discovery Hub Dortmund

@DDHDortmund

Overcoming the #InnovationGap by translating #BasicResearch into #Pharmaceutical Application. #Medicinal #Chemistry, #Chemical #Biology

Dortmund, Germany ddhdortmund.de Joined April 2018

129 Following 492 Followers 279 Posts

Latest posts 5

Drug Discovery Hub Dortmund @DDHDortmund Mar 5

🚨 New must-read from the AG Rauh group!

Lessons from Structural Biology for Understanding Drug Resistance in Gastrointestinal Stromal Tumors (GIST)” by Mancino et al. 🔬🧬
👉 pubs.acs.org/doi/10.1021/ac…

#GIST #CancerResearch #DrugResistance #MedChem #Oncology

Drug Discovery Hub Dortmund @DDHDortmund Jan 30, 2025

Fighting drug-resistant GIST!🚀 We developed innovative covalent KIT/PDGFRA inhibitors using structure-based design. Check out our latest J Med Chem publication! doi.org/10.1021/acs.jm…

#CancerResearch #DrugDiscovery

Drug Discovery Hub Dortmund @DDHDortmund Oct 10, 2024

Promising substance against rare cancer licensed out!
Full article here: tu-dortmund.de/detail/vielver…

Drug Discovery Hub Dortmund @DDHDortmund Jul 15, 2024

Big News: National network for the development of cancer drugs launched - the Deutsche Krebshilfe foundation is funding the national research network "TACTIC" with 11.8 million euros over five years!

Read more: tu-dortmund.de/detail/nationa…

Drug Discovery Hub Dortmund @DDHDortmund Apr 16, 2024

Taking it to the next level - Targeting KRAS Diversity: Covalent Modulation of G12X and Beyond in Cancer Therapy | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

pubs.acs.org Targeting KRAS Diversity: Covalent Modulation of G12X and Beyond in Cancer Therapy Abstract. The GTPase KRAS acts as a switch in cellular signaling, transitioning between inactive GDP-bound and active GTP-bound states. In about 20% of hum