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DavidMacPherson

@DMacPhersonLab

Cancer Biologist @fredhutch
Seattle, WA research.fhcrc.org/macpherson/en.… Joined February 2019
208 Following 338 Followers 109 Posts

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DavidMacPherson @DMacPhersonLab
Thanks for highlighting our efforts to use in vivo CRISPR screens to identify drivers of resistance to chemotherapy in small cell lung cancer
In work published in Science Advances, researchers in the @DMacPhersonLab used #CRISPRCas9 on #SCLC tumor cells to better model how tumors that initially respond to chemotherapy become resistant. bit.ly/4krzUTn
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DavidMacPherson @DMacPhersonLab
Our collaborative study with @GavinHa @fredhutch is out in @ScienceAdvances. Led by Joe Hiatt and Anna Lisa Doebley, we developed a liquid biopsy approach, SCLCpheno-seq, to classify SCLC subsets and distinguish from NSCLC based on analyses of ctDNA 1/X science.org/doi/10.1126/sc…
www.science.org Molecular phenotyping of small cell lung cancer using targeted cfDNA profiling of transcriptional... Targeted cell-free DNA nucleosome profiling at transcriptional regulatory regions can distinguish lung cancer types and subtypes.
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