🌟 Exciting News! Eric has been named #PostdocOfTheMonth! 🎉 Check out the full interview on the university's daily news site! thedaily.case.edu/postdoc-of-the… #ScienceSpotlight [Link to interview] 📚🔬
TheTaylorLab
@DTaylorLab
Research lab at Case Western Reserve University using structural biology, molecular mechanism, and cellular outcome to understand and treat cancer.
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🦠🧬 Dive into the fascinating world of how bacteriophage T4 ingeniously hijacks E. coli's cellular machinery! Unveil the intriguing process of ‘RNAylation’! RNAylation-installing RNA strands onto the arginine residues of target proteins. #RNAylation
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nature.com/articles/s4158…
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nature.com/articles/s4158…
www.nature.com A viral ADP-ribosyltransferase attaches RNA chains to host proteins Nature - Bacteriophage T4 uses an enzyme known as ADP-ribosyltransferase ModB to modify the translational apparatus of bacteria it infects, not only by ADP-ribosylating proteins, but also by... 🎉 Kudos to @vignesh_k757 and Cech team for revealing a stunning structure & applying streptavidin grids innovatively! Shedding light on the fascinating functional role of G4 RNA, pushing the boundaries of our understanding. Fantastic achievement!
science.org/doi/10.1126/sc…
science.org/doi/10.1126/sc…
www.science.org Structural basis for inactivation of PRC2 by G-quadruplex RNA Cryo–electron microscopy structure of RNA-bound PRC2 dimer elucidates an unexpected mechanism of PRC2 inhibition by RNA. 🎉 Huge congrats to Brendan Sheehan for securing a training grant from the National Institute of General Medical Sciences! 🎓 So proud of this remarkable achievement. Onward and upward! 🌟 #NIGMS #T32 #FutureOfScience #GrantAchievement 🙌🔬
Ever wonder about the hidden costs of drug toxicity? The latest research sheds light on an often overlooked area: the impact of off-target drug interactions on intracellular RNAs. 🧬
#DrugSafety #Transcriptomics #Pharmacology #Toxicity #Innovation
nature.com/articles/s4155…
#DrugSafety #Transcriptomics #Pharmacology #Toxicity #Innovation
nature.com/articles/s4155…
www.nature.com Pervasive transcriptome interactions of protein-targeted drugs Nature Chemistry - Now a reactivity-based RNA profiling strategy can measure the global off-target transcriptome interactions of small-molecule drugs at single-nucleotide resolution. Using this...