Daniel del Toro

I am looking for two postdocs (fully funded, up to 6 years) and one technician to join my lab for an ERC-funded project.
If you are passionate about cell–cell communication and migration in neurodevelopmental tumors, consider applying.The starting date is flexible. Links below.

Super happy to be awarded a competitive ERC Synergy grant together with Valérie Castellani @CastellaniLab and Elena Seiradake @ERC_Research . An amazing team studying the molecular mechanisms driving cell-cell communication in neuro-developmental tumors. #ERCSyG @UBneuroscience

Happy to see that our collaborative study with the Klein lab and @neurocientific is out in @CellStemCell! We show that transient reprogramming leads to cortex expansion and improved behavior. Similar induction in adults prevents several Alzheimer’s disease hallmarks. cell.com/cell-stem-cell…

Happy to have contributed to this preprint from the Klein lab, with amazing work from SeungHee. When we published the FLRT1/3 DKO phenotype, inducing cortex folding by altering neuronal migration , an open question was whether progenitor expansion could intensify this phenotype. Here, we show that both mechanisms, divergent migration and progenitor amplification, synergize to promote cortex folding. Interestingly, depending on the type of cortical progenitor that is expanded, the proportion of cortical neurons with different adhesive properties varies, and this influences the formation of gyri or sulci.
biorxiv.org/content/10.110…

Happy to share our collaborative preprint with @neurocientific and Ruediger Klein. We show that Yamanaka factors induction expand the cortex and enhance cognitive skills. Moreover, their induction protect against neurodegeneration in a mouse model of AD. biorxiv.org/content/10.110…