Jack Little Symposium coming up.... Innovation in Radiation Sciencesโผ๏ธ
What a beautiful day to be listening to the one and only @rweichselbaum . The Q&A should be one for the ages๐
@HarvardChanSPHView quoted post on X
๐๐ถ๐ผ๐น๐ผ๐ด๐ถ๐ฐ ๐จ๐ป๐ฑ๐ฒ๐ฟ๐ฝ๐ถ๐ป๐ป๐ถ๐ป๐ด๐ ๐ผ๐ณ ๐ฆ๐ถ๐ฑ๐ฒ ๐๐ณ๐ณ๐ฒ๐ฐ๐๐ ๐ผ๐ณ ๐ฅ๐ฎ๐ฑ๐ถ๐ฎ๐๐ถ๐ผ๐ป
Radiobiologic models developed with the use of characteristics such as mitotic capacity, tissue hierarchy, and differentiation state can predict responses in normal tissue at the levels of the cell, tissue, and organ. For example, the interaction of the dose and volume of radiation with the risk of effects in normal tissue is tissue- or organ-specific and dependent on the organization of the smallest functional subunits (e.g., nephrons, neurons, or alveoli) within the tissue. For some organs in which the functional subunits are organized in parallel (e.g., nephrons in the kidney), approximately a third of the total volume of the organ must be spared from receiving a relatively low threshold dose to maintain functional organ viability. The remaining two thirds of the organ constitutes a functional reserve. In contrast, when functional subunits are arranged in series (e.g., spinal cord neurons), even a focal injury threatens organ function (e.g., spinal cord myelopathy). Tissues with parallel organization generally have a higher tolerance for radiation than tissues with serial organization. Ablative treatments such as stereotactic ablative radiotherapy are more likely to have an acceptable safety profile when applied in and around tissues with parallel organization or in tissues capable of compensatory hyperplasia after injury than in serially functioning tissues (seen in figure).
Learn more in the Review Article โEffects of Radiotherapy in Normal Tissueโ by @DeborahCitrin, MD, and Robert D. Timmerman, MD (@BobTimmermanMD), from the National Cancer Institute and @UTSWMedCenter: nejm.org/doi/full/10.10โฆView quoted post on X
@IBCradiation Hmmm those are quite high pneumonitis numbers. Curious that steroids during RT would be effective like that? @DeborahCitrinView quoted post on X
๐ฃ
The GU Malignancies Branch @NCIResearchCtr welcomes Dr. Melissa Abel @melissaabel20 as a clinical investigator on the #ProstateCancer team
Dr. Abel has previously done research in small cell cancers including Prostate. She also earned an @asco YIA.
Welcome Dr. Abel๐๐๐View quoted post on X
