The Fallopian Tube’s Secret Bodyguards 🛡️
I am thrilled to share our lab’s latest study which flips the script on how we think about the origins of ovarian cancer. For a long time, ciliated cells in the fallopian tube were seen as "passive bystanders" in tumor development.
Our research reveals they are actually active guardians of genomic integrity. We found that these cells use a STING-driven surveillance mechanism to act as a biological "cleanup crew," clearing away damaged cells before they can turn into high-grade serous carcinoma (HGSC). When these "gatekeepers" are lost, the door swings wide open for cancer to initiate.
This discovery shifts our understanding of the epithelial microenvironment and points toward new strategies for early prevention.
aacrjournals.org/cancerres/arti…
@UMich @UMRogelCancer @CR_AACR @UMichPath
I am thrilled to share our lab’s latest study which flips the script on how we think about the origins of ovarian cancer. For a long time, ciliated cells in the fallopian tube were seen as "passive bystanders" in tumor development.
Our research reveals they are actually active guardians of genomic integrity. We found that these cells use a STING-driven surveillance mechanism to act as a biological "cleanup crew," clearing away damaged cells before they can turn into high-grade serous carcinoma (HGSC). When these "gatekeepers" are lost, the door swings wide open for cancer to initiate.
This discovery shifts our understanding of the epithelial microenvironment and points toward new strategies for early prevention.
aacrjournals.org/cancerres/arti…
@UMich @UMRogelCancer @CR_AACR @UMichPath
