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Sergej Djuranovic

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@DjuranovicLab

Biochemistry, Genetics and RNA biology lab at Brown University RNA Center.
Providence, RI rna.brown.edu Joined September 2018
307 Following 1.4K Followers 950 Posts

Latest posts 5

Sergej Djuranovic Verified account @DjuranovicLab
One of the coolest use of RAPPL by John McCutcheon and @IsraelF96135088 . They RAPPL isolated ribosomes of bacterial endosymbiont from 2 cicadas and solve structures of funky (mosaic) ribosomes.
Great work here and very happy that our method help them solve this long awaited structure.
Israel Fernandez @IsraelF96135088 Oct 23
Today is an emotional day for me. Together with Prof. John McCutcheon lab @ASU we have visualized by cryoEM what looks like a very funky ribosome from an insect endosymbiont.
We believe there are important evolutionary implications.
Here the pre-print:

biorxiv.org/content/10.648…
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Sergej Djuranovic Verified account @DjuranovicLab
This is a great collaboration with @CKChenLab, @slavicaPD Lab, and multiple other labs (Dai, He, Larsson and Topisirovic) that uses our RAPPL method of ribosome isolation for ribosome profiling of mouse tissues or human biopsies (glioblastoma and lung samples). It heavily reduces time for isolation of ribosomes and creation of libraries from scarce and not easy to process samples.
Chun-Kan Chen @CKChenLab Oct 22
Excited to share our work with @DjuranovicLab on bioRxiv, introducing RAPPL-Seq! 🧬

doi.org/10.64898/2026.…

#RNA #RiboSeq
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Sergej Djuranovic Verified account @DjuranovicLab
This is the first of multiple manuscripts that use our patented approach to increase protein production in gene specific way from a wild type allele in happloinsufficiencies using antisense oligonucleotides (ASOs). Great collaboration with @MillerLabNeuro and funded by @CZI. Many more manuscripts and ASOs to come in the near future.

Protein expression is amplified by stabilizing mRNA using gene-specific antisense oligonucleotides biorxiv.org/content/10.648…
www.biorxiv.org Protein expression is amplified by stabilizing mRNA using gene-specific antisense oligonucleotides Effective and safe strategies to restore gene expression in haploinsufficiency disorders or to augment protective protein signaling have long been attractive but challenging therapeutic goals. Here,...