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Doug Simonetto, MD

@DougSimonetto

Program Director GI & Hep @MayoClinicGIHep | Transplant Hepatologist | ALD & portal hypertension, #telomeres, #AI, #innovation |πŸ³οΈβ€πŸŒˆπŸ‡§πŸ‡·πŸ‡ΊπŸ‡ΈHe/him #HeForShe
Minnesota, USA Joined November 2015
2.3K Following 4.9K Followers 1.9K Posts

Latest posts 5

Doug Simonetto, MD @DougSimonetto
So proud of our superstar 2nd year GI fellow @AlsakarnehSaqr on winning 1st place in the @AmCollegeGastro EndoTitans!! #ProudPD #FutureOfGI
Please join us in congratulating our own @SaqrAlsakarneh on 1st-place finish in the 2026 ACG EndoTitans Challenge!

This national competition brings together trainees from across the country to showcase their endoscopic skill, precision, and technical expertise and Mayo Clinic represented by Dr. Saqr Alsakarneh, rose to the top! πŸŽ‰

We are incredibly proud of this outstanding achievement and the dedication it represents. Help us celebrate this well-deserved win of our skilled fellows! πŸ‘
#ACG2026 #GITwitter #Endoscopy”
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Doug Simonetto, MD @DougSimonetto
Excited to share that the ITAALD trial has been officially launched!

This trial is investigating IL-22 followed by AUD tx in severe alcohol-associated hepatitis, building on promising phase 2 results:
pubmed.ncbi.nlm.nih.gov/31774566/

@AlcHepNet @NIAAAnews @Dr_Vijay_Shah @juanpabloarab
pubmed.ncbi.nlm.nih.gov An Open-Label, Dose-Escalation Study to Assess the Safety and Efficacy of IL-22 Agonist F-652 in... F-652 is safe in doses up to 45 ΞΌg/kg and associated with a high rate of improvement as determined by Lille and MELD scores, reductions in markers of inflammation and increases in markers of hepatic...
AlcHepNet @AlcHepNet Feb 25
First post + big milestone! πŸŽ‰

The ITAALD Trial has officially enrolled its first patient in January. Huge thanks to our investigators and site teams for making this happen.

We’re just getting started. #ITAALD #ClinicalTrials
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Doug Simonetto, MD @DougSimonetto
Excited to share the results of the DULCE trial! 🚨

Grateful for this incredible partnership with Cardiology, IT, Family Medicine/Primary Care and the BEST team!!
@zachia5 @AlbCalle @JosephCAhnMD @Puru_MD @AlinaAllenMD @Dr_Vijay_Shah @NatureMedicine

πŸ‘‰πŸ½ nature.com/articles/s4159…
Mayo Clinic Verified account @MayoClinic Dec 17, 2025
Advanced liver disease is often silent. Mayo Clinic researchers built an AI model that helps doctors detect it earlier β€” even without symptoms β€” so care can begin sooner.

Read more:
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Doug Simonetto, MD @DougSimonetto
Thrilled to announce our new fellowship class @MayoClinicGIHep! Another talented group of future leaders in GI!

Welcome to the Mayo family!! @AmerGastroAssn @AASLDtweets @AmCollegeGastro #FellowshipMatch
A huge welcome to our 2026 GIH fellowship class! πŸŽ‰

We’re proud to bring together this remarkable group of trainees committed to advancing patient care, research, and innovation in GI and Hepatology. The future is bright with you all on our team! 🌟

#GIMatch #MedicalEducation #FutureofGI #Match2026
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