Adam Sharples Ph.D -Blue Sky🦋@profadamsharples

@DrAdamPSharples

Our Group 1st Demonstrated that Human Muscle possesses an Epigenetic Memory of Exercise -Our DNA remembers exercise! | ExProRugby | Judo

Oslo, Norway nih.no/english/about/… Joined October 2010

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Adam Sharples Ph.D -Blue Sky🦋@profadamsharples @DrAdamPSharples Feb 25

Our new study is now published in Advanced Science

We show that skeletal muscle retains a molecular memory of disuse

Young muscle shows transcriptional resilience

Aged muscle shows exaggerated vulnerability

advanced.onlinelibrary.wiley.com/doi/10.1002/ad…

@nih_sognsvann @nih_physicperf

Adam Sharples Ph.D -Blue Sky🦋@profadamsharples @DrAdamPSharples Oct 24

Fantastic to present at the Department of Molecular Medicine, University of Pavia 🇮🇹 yesterday & catch up with good friends & colleagues @dcturner93 @PorcelliSimone @andreapil8. Pavia is one of Europe's oldest universities and was home to Nobel laureate Camillo Golgi (1906).

Adam Sharples Ph.D -Blue Sky🦋@profadamsharples @DrAdamPSharples Oct 23

It also raises an intriguing exercise biology question: could CRISPR-based epigenetic editing be used to reinforce exercise-induced molecular memories, allowing beneficial adaptations to persist longer during ageing, injury, or disuse?

Adam Sharples Ph.D -Blue Sky🦋@profadamsharples @DrAdamPSharples Oct 23

As someone studying exercise-induced epigenetic memory, my first thought was: "we call this exercise". Mechanical loading deforms muscle fibres and nuclei. Do loading and unloading leave lasting mechano-epigenetic signatures that shape adaptive capacity with ageing?
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Adam Sharples Ph.D -Blue Sky🦋@profadamsharples @DrAdamPSharples Oct 23

As someone studying exercise-induced epigenetic memory, my first thought was: "we call this exercise". Mechanical loading deforms muscle fibres and nuclei. Do loading and unloading leave lasting mechano-epigenetic signatures that shape adaptive capacity with ageing?

David Sinclair Verified account @davidasinclair Oct 23

Never thought to squeeze a cell
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Adam Sharples Ph.D -Blue Sky🦋@profadamsharples @DrAdamPSharples Oct 23

Fascinating! Could exercise-induced myonuclear deformation contribute to skeletal muscle epigenetic memory? We observed persistent mechanotransduction gene regulation after training. Does mechanical loading help establish chromatin states that shape future adaptation?

Prof Steve Horvath Verified account @prof_horvath Oct 22

Squeezing a fibroblast nucleus for a moment opens chromatin at mappable loci. Yang Song and Song Li at UCLA aimed CRISPRa guides at exactly those spots. Fibroblast to neuron conversion went from under 3% to about 40%, with no virus. In aged mouse fibroblasts, the same mechanically enhanced Oct4 activation lowered DNA methylation age on the mouse skin clock, close to the level of cells from young animals. But global methylation also drops. so how much of this is rejuvenation rather than dilution is the open question. Title: Mechano-epigenetic enhancement of CRISPR activation of target genes fo… sciencedirect.com/science/articl…
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