Michael Booth

@DrMikeBooth

Associate Prof of ChemBio+OrgChem @UCLChemistry @RoyalSociety URF chemistry, DNA/RNA, synthetic biology. Coeliac. Dad. 🎸

London, England boothlab.uk Joined April 2016

529 Following 4.8K Followers 7.7K Posts

Latest posts 5

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Michael Booth @DrMikeBooth Jun 23, 2025

We have developed an entirely new mechanism of action for gene knockdown -> trafficking of targeted mRNAs to the lysosomal, using lysosomal trafficking oligonucleotides (LyTONs)!

Published in @ChemicalScience

Led by @disha_kashyap_, with @milnetom68
pubs.rsc.org/en/content/art…

pubs.rsc.org Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking† Antisense oligonucleotides (ASOs) can modulate gene expression at the mRNA level, providing the ability to tackle conventionally undruggable targets and us

Michael Booth @DrMikeBooth Oct 25

Delighted our magnetically activated synthetic cell research has been made into this cool teaching resource! Big thanks to the @SJforKids team

ScienceJournal4Kids @SJforKids Oct 21

Check out our new article - sciencejournalforkids.org/articles/how-c… to learn about how researchers built tiny magnetic particles that act like on-off switches for protein production that only turn on in a magnetic field. Magnetic fields can reach deeper into the body than light, and are safe.
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Michael Booth @DrMikeBooth Jul 15

🚨 Preprint alert 🚨 We’ve used in vitro transcription and DNA nanotechnology to programme the localisation of DNA within synthetic cells!

We also developed designs+processes to integrate these systems for synthetic cell applications

Led by Chelsea

biorxiv.org/content/10.648…

www.biorxiv.org Programmable and Dynamic DNA Localisation at Synthetic Cell Membranes Spatial and temporal organisation of membrane-associated components is fundamental to cellular signalling, yet remains difficult to engineer in minimal synthetic systems. In synthetic cells, DNA and...

Michael Booth @DrMikeBooth Jul 8

Our review paper on Membrane-Associated Biomolecules for Synthetic Cell Signalling has just been published in @ChemBioChem!

Led by Chelsea and Bingkun

@UCLChemistry @SigSynCell @LIDo_DTP
…mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cb…

chemistry-europe.onlinelibrary.wiley.com Membrane‐Associated Biomolecules for Synthetic Cell Signalling Membrane-associated proteins and nucleic acids are transforming synthetic cell communication, unlocking applications in biosensing, therapeutics, and tissue engineering. This review explores how...

Michael Booth @DrMikeBooth Feb 10

It's an incredible honour to be selected as a Finalist for the Blavatnik Awards in the UK in Physical Sciences

I'm thankful to all my past and present group members, whom I have had the privilege to work with, and my collaborators and mentors.

Blavatnik Awards @BlavatnikAwards Feb 10

📣Announcing the shortlisted Finalists 🏅 of the 2026 @BlavatnikAwards in the 🇬🇧
➡️ blavatnikawards.org/news/items/you…

@ucl @EdinburghUni @imperialcollege @OfficialUoM @LSTMnews @MathewHHorrocks @nickcasewell @DrMikeBooth @TheCrick @pontus_skoglund @BangorUni @KellyTHD_Nguyen

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