@ElevyLab
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Huge kudos to @WeizmannScience's @Sys_Immunology Yifat Merbl, included in @Nature's 10.View quoted post on X
This scientist found a new trick of the immune system by digging through cellular rubbish nature.com/articles/d4158…
link.springer.com Mutation-induced filaments of folded proteins are inert and non-toxic in a cellular system Molecular Systems Biology - Filamentous protein assemblies are essential for cellular functions but can also form aberrantly through mutations that induce self-interactions between folded protein... Years ago, we discovered that missense mutations in homomeric proteins can induce their supramolecular assembly, as in the 📽️👇 - Question: how are such aberrant assemblies of *folded* proteins handled in a eukaryotic cell? The answer here: biorxiv.org/content/10.110… + 🧵 belowView quoted post on X
Foldseek-Multimer is a strategy for complex-to-complex protein structure alignment to quickly perform large-scale structural comparisons between complexes. @thesteinegger @ElevyLab
nature.com/articles/s4159…View quoted post on X
🔥Cell biology meets structuromics🔥 1000s of proteins assemble co-translationally but we don't know why🤷♂️ @Robb_Mallik found it’s all about protein 🧩structure🧩, with implications for #gene_expression, #proteostasis, #evolution & #mRNAlocalization 🧵👇
biorxiv.org/content/10.110…View quoted post on X
