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Discover PF-06658607, an alkynylated irreversible Bruton’s tyrosine kinase (BTK) inhibitor designed for research into covalent kinase inhibition.
View the product details here: ebc.enamine.net/molecule-produ…

PF-06658607 selectively targets the active-site cysteine within the ATP-binding pocket of BTK, forming a covalent bond and providing a valuable tool for investigating irreversible kinase inhibition.
A distinctive feature of this compound is its alkyne functional group, which enables the attachment of azide-containing detection probes through copper-catalyzed click chemistry. This approach makes PF-06658607 particularly useful for identifying and profiling potential off-target interactions of covalent kinase inhibitors in cancer cells.

Learn more about PF-06658607: pubmed.ncbi.nlm.nih.gov/25038787/
Explore Enamine’s @pfizer Reference Compound Collection to discover a diverse range of bioactive molecules for research across multiple therapeutic areas: ebc.enamine.net/categorized-pr…

Replacing benzodioxole motif with its aza-analogues may help improve the substance’s solubility, lower lipophilicity, and create contact interactions with the target protein residues: bit.ly/4C0cnT9

Try heterocycles in your research!

The Ruppert–Prakash reagent (TMSCF₃) has become an important tool in difluorocarbene chemistry, enabling the synthesis of diverse 𝘨𝘦𝘮-difluorocyclopropane and 𝘨𝘦𝘮-difluorocyclopropene frameworks.

This review examines advances in understanding the reaction mechanisms and reactivity of TMSCF₃, as well as its applications in the synthesis of three- and four-membered rings from alkenes, alkynes, and more complex functionalized substrates. It also highlights strategies such as slow addition, catalytic approaches, and flow chemistry that improve reaction efficiency, safety, and scalability.

The review is co-authored by Serhiy Ryabukhin, Pavel Nosik, Dmytro Leha, Dmytro Volochnyuk

Read more: doi.org/10.1002/ijch.7…

Molecule of the week EN300-52955156
enaminestore.com/catalog/EN300-…

Discover all the molecules of the week here: enamine.net/molecule-of-th…

#Enamine #molecule #chemistry #science #drugdiscovery

Four days of scientific exchange, new connections, and inspiring discussions at the Enamine Drug Discovery Conference 2026, which took place in beautiful Riga, Latvia.

Thank you to everyone who made this event special!

Take a look back at the highlights and watch the full video on YouTube: youtu.be/TbwEzwL6Txo

#EnDDC #DrugDiscovery #MedicinalChemistry