Thrilled to share this #bioorthogonal story in @angew_chem from our lab and in collaboration with @houk1000 lab. We describe the development and use of a super fast and fluorogenic cyclooctyne probe.
onlinelibrary.wiley.com/doi/10.1002/an…
onlinelibrary.wiley.com/doi/10.1002/an…
onlinelibrary.wiley.com Photo‐Triggered, Fast, and Fluorogenic Thiophene‐Based Cycloalkynes for the Bioorthogonal Fluores... Thiophene is king! The fusion of thiophene rings to cycloalkynes super-charged their copper-free click chemistry applications, by (1) enhancing the alkyne reactivity (fastest cyclooctyne to date)... 
