The stress-inducible protein Sestrin2 (SESN2) controls OXPHOS, supports mitochondrial biogenesis & regulates mitochondrial dynamics (Machado et al., 2026, febs.onlinelibrary.wiley.com/doi/10.1111/fe…).
Felix Scholkmann
@FScholkmann
Researcher/Lecturer@UZH_ch | Neurophotonics, functional neuroimaging, integrative human physiology, biophysics, signal processing, physics, philosophy and more
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Current guidelines in the US, UK & CA shift the standard for declaring death from "irreversible" to "permanent" loss of function. A problematic decision according to Beckmann & Stoffel (smw.ch/index.php/smw/…). I agree.
New study: psychdelics activate both Gq/11 & Gi1 proteins via 5-HT2ARs. Non-hallucinogenic agonists don't activate Gi1, revealing Gi1 engagement as a key driver of the psychedelic state (Miranda-Azpiazu et al., 2026, sciencedirect.com/science/articl…).
Embodied Dynamic Causal Modelling: an extension of the DCM framework to model the cortical-brainstem-cardiac axis (Levy et al., 2026, biorxiv.org/content/10.648…).
Spin-orbit coupling , a relativistic quantum-mechanical phenomenon, could play a role in explaing the effects of anesthetics (Melegari et al., 2025, sciencedirect.com/science/articl…).
Halothane destroys spin-coherence (→ impaired cellular O2 metbaolism)
Halothane destroys spin-coherence (→ impaired cellular O2 metbaolism)
