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Fabrizio d'Adda di Fagagna
@FdAdF66
Principal Investigator @IFOMresearch and IGM-CNR. Begging to differ.
681 Following 1.4K Followers 557 Posts
Latest posts 5
🚨 Can we kill a cell by targeting DNA that does nothing?
🧬 Our study shows Cas9 can selectively kill cells carrying a non-functional target sequence, sparing cells without it.
Weaponizing CRISPR/Cas9 for selective elimination of cells with an abe… sciencedirect.com/science/articl…
🧬 Our study shows Cas9 can selectively kill cells carrying a non-functional target sequence, sparing cells without it.
Weaponizing CRISPR/Cas9 for selective elimination of cells with an abe… sciencedirect.com/science/articl…
🚨 Can broken DNA generate a new protein?
Our study independently confirms that DSBs trigger transcription from the break—and shows, for the first time, that the resulting RNA can be translated.
Could this generate neoantigens after radio/chemotherapy?
nature.com/articles/s4200…
Our study independently confirms that DSBs trigger transcription from the break—and shows, for the first time, that the resulting RNA can be translated.
Could this generate neoantigens after radio/chemotherapy?
nature.com/articles/s4200…
www.nature.com Site-specific DNA double-strand break induces local transcription in cis and protein expression Communications Biology - DNA double-strand breaks function as promoter-like elements that drive transcription and protein synthesis of polyadenylated RNAs from otherwise silent DNA regions. #IPF has no cure. Median survival: 4 years. Lung transplant is the only real option.
Our new paper shows this might be about to change. 🧵
Our new paper shows this might be about to change. 🧵
1/ What if some of the consequences of #aging are not caused by damage itself, but by the alarm signals our cells generate in response to that #damage?
Today, we publish a study in @NatureAging addressing this question.
nature.com/articles/s4358…
Today, we publish a study in @NatureAging addressing this question.
nature.com/articles/s4358…
www.nature.com Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by... Nature Aging - Oppezzo and colleagues report that therapeutically blocking telomeric DNA damage signaling reduces senescence and inflammation and restores hematopoietic function in...