Tristan Ferry

Thanks 🙏 a lot! I'm delighted to be able to share the experience I've gained with patients who deserve to have everything possible done to make this treatment possible!

🤩 What a great 🔥 chapter, this #EBJIS2024 congress in Barcelona 🇪🇸!

What a pleasure for me to belong to this magic board ✨ that includes orthopaedic surgeons and infectious diseases physicians friends from so beautiful countries that make Europe what it is: diverse, respectful, friendly, productive, and so human- and team-based!

It was an honor for me to report how #phage therapy could help for the treatment of patients with prosthetic joint infection (#PJI) in the era of multi-drug resistance! What a crucial question, as antimicrobial resistance is a tsunami 🌊 leading to limited treatment options, and severe individual consequences. #Bacteriophages are clearly an option, as adjuvant, to face this huge problem. I reported the literature review that we recently published this month with the team of my colleague and friend Pr. Sebastien Lustig (see here ➡️ link.springer.com/article/10.100…) and presented how we managed the 4 patients who were treated at our institution Hospices Civils de Lyon - HCL 🇫🇷 with phages from @PHAXIAM, from @BiomX_Inc and from academic sources. Indeed, for a patient infected with a multidrug resistant Staphylococcus epidermidis and for whom no phages from the industry were available, a phage isolated by colleagues (🙏) at @inselgruppe in Bern🇨🇭that looked to be active was then purified by the Queen Astrid military hospital in Brussels 🇧🇪 (🙏) before being mixed in an active cocktail that was successfully administered in 🇫🇷! I presented also the various therapeutic schemes we developed and currently applying depending on the patient clinical presentation. The standard exposure (Std-Ex.) is now three injections with a one week interval, a scheme that has been included, based on our experience, in the next clinical trial promoted by @PHAXIAM. I presented also the clinical case of patients who received or maximum exposure (Max-Ex.) that includes intravenous infusons of phages and a total of 9 local injections during a therapeutic scheme of three weeks!

All of that was possible thanks to the indefectible dedication of my colleagues (🙏) and to the support of the @FondationHCL to our program #PHAGEinLYON_Clinic that aims to make #phagetherapy possible and more and more common in Lyon!

We will go ahead now to publish soon our experience, and it’s absolutely sure that there will be more and more talks and works on the topic of phage therapy at #EBJIS2025 @EBJIS_ in Bologna 🇮🇹! Our patients crucially need this development, and treating them is definitely like a piece of art 🎨 or a jazz 🎶 partition played collectively: it requires inspiration, motivation, training, interaction, improvisation and succeed in showing that it works!

🙏 Thanks to all of my friends from the board, and to the @CapPartner team for the incredible interactions we have! Thanks to all attendees and sponsors for their enthusiasm! See you next year for another great chapter of this fantastic tale ✨!

👋 it’s time 🕰️ to register to the @ESCMID #ESGNTA exclusive onsite workshop (no live webcast) entitled "State of the Art Clinical Evidence for the Use of Phage Therapy in Clinical Practice: the Pathways for Efficacy" that will take place in Lyon the 12-13th November 2024 ➡️ escmid.org/event-detail/s…!

Download the updated program here ➡️ escmid.org/fileadmin/escm…, and register here ➡️ members.escmid.org/login?ReturnTo… to come and meet in person the world experts in the field of clinical #phage therapy 🤩 ! Such a honor for me to organize this incredible event and to make Lyon the world capital of #bacteriophage therapy during 2 days!

We are ready to welcome you in 2 months 🔥! Do you know that Lyon is the city of Lights ✨? The Lyon city has a huge history and was called Lugdunum. It was an important Roman city, the capital of Gaul that was part of current Western Europe. Lyon has a rich architectural heritage through the centuries. The Festival of Lights (Fête des lumières) is celebrated every year on December 8 to mark the city's victory over the last plague epidemic, which ravaged the city and ended on December 8, 1852 (we don't know if natural #phages were involved as a player in such eradication!). It was particularly important for me to set up the course in a significant location and it will take place in the hangar of the 1st film 🎬, where the first movie 🎞️ in the story of cinema was recorded 🎥 by the brothers « Lumière » (Light ✨ in English), named Auguste and Louis Lumière. You will sit in a highly comfortable cinema seat and you have to know that you will be in the venue that welcome the annual International Lumiere Film Festival each year in October (institut-lumiere.org)!

We are excited to welcome our hosts with @MCOCongres in particular fantastic conditions. Here are below some 📸 to share you the current atmosphere waiting you!

I love ❤️ my city ✨ I love ❤️ my country 🇫🇷!
So happy and excited to welcome the faculty and attendees here!

Register and participate to the #phage history, an incredible ✨ film 🎥 that is still ongoing (we don’t know the end, but I think that we have together the ability to influence it)!

Thanks 🙏 to all our partners @FondationHCL Vésale Bioscience @Jafral1 BiomX Inc @ATechnophage Armata Pharmaceuticals, Inc. for their educational support!

@OnlyLyon @villedelyon @CHUdeLyon @HCL_research @UnivLyon1 @InstitutLumiere @Inserm @CNRS @Sante_Gouv @esgnta

📸 Credits (1, 2: T. Ferry; 3: Velvet)
1 Chapelle de l’Hotel-Dieu
2 Muse de l’Opera
3 Hangar du Premier Film

😀 I'm delighted to have been able to treat with #phages this burned ICU patient, cared for by my intensivist colleagues at @CHUdeLyon Hôpital Edouard Herriot, and who was suffering from recurrent extensively drug-resistant #Pseudomonas aeruginosa ventilator-associated pneumonia (#VAP) that was threatening his vital prognosis mdpi.com/1999-4915/16/7…

Phage therapy is promising in severe bacterial infections due to multidrug- and extensively-drug resistant P. aeruginosa, but very few patients can be treated in the #ICU at this time. In fact, there is a long time lag between isolating and characterizing bacteria, thinking about #phagetherapy, sending the strain for in vitro testing of phage activity, selecting active pharmaceutical-grade #bacteriophages, and receiving them for clinical use. It could take a minimum of 7-10 days, that is frequently not compatible with treatment in emergency. Here, phage therapy was made possible thanks to the experience acquired at @CHUdeLyon in the treatment of joint prosthesis infections at @CrioacLyon, by the development of the #PHAGEinLYON_Clinic program supported by the @FondationHCL, by the proximity that we have as infectiologists with intensivists, and by the fact that we were able to anticipate a potential relapse of this serious infection. Indeed, the patient was able to be treated rapidly at the time of the relapse, as we had previously assessed the possibilities of subsequent phage therapy during the first episode. Thanks 🙏 to all people who participated to this effort!

Thanks to the #PHAGEinLYON_Clinic program, at this time, we have so far treated 84 patients at HCL, including 4 serious pulmonary infections. There is indeed a need to extend phage therapy beyond bone and joint infections, notably as an adjuvant treatment for severe bacterial infections such as infections in intensive care units, infections on vascular implants, endocarditis and in some chronic lung infections. This experience is currently crucial, is a considerable hope, is being valorized, and will be reported at the @ESCMID @esgnta workshop to be held in Lyon on November 12-13, 2024 (program: escmid.org/fileadmin/escm…; registration: escmid.org/event-detail/s…).

Come with us to share the knowledge about phage therapy! The future is viral!

@CHUdeLyon @FondationHCL @ansm @PHAXIAM