Fitzpatrick Laboratory

@FitzpatrickLab

Assistant Professor @ZuckermanBrain @ColumbiaBiochem. Lab uses cryo-EM & biophysics to study the cellular, molecular, and structural basis of neurodegeneration.

New York, NY fitzpatrick-lab.org Joined January 2013

5K Following 3.4K Followers 3.3K Posts

Latest posts 5

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Fitzpatrick Laboratory @FitzpatrickLab Oct 27

Amyloid Fibrils Protect the Father’s Genetic Message - neurosciencenews.com/amyloid-fibril…

neurosciencenews.com Amyloid Fibrils Protect the Father’s Genetic Message - Neuroscience News A new study reveals amyloid proteins in semen shepherd RNA into sperm cells, explaining paternal epigenetics and offering a new delivery tool for CRISPR.

Fitzpatrick Laboratory @FitzpatrickLab 15h

Transient nuclear softening for zygotic gene activation in mice | Nature share.google/lWimphx1BQUdPk…

www.nature.com Transient nuclear softening for zygotic gene activation in mice Nature - A distinct physical nuclear state acquired by embryos at the beginning of life supports the initiation of the zygotic transcription program.

Fitzpatrick Laboratory @FitzpatrickLab Nov 6

drugdiscoverynews.com/amyloid-fibril…

www.drugdiscoverynews.com Amyloid fibrils help deliver RNA into sperm and embryos | Drug Discovery News Often associated with neurodegenerative disease, amyloid fibrils may also help transport genetic material during fertilization.

Fitzpatrick Laboratory @FitzpatrickLab Nov 3

studyfinds.com/dads-diet-may-…

studyfinds.com Dad's Diet May Reach Embryos Via Alzheimer's-Like Clumps In Semen Mouse experiments suggest Alzheimer’s-like clumps in semen carry RNA into early embryos. What it means for dads, explained.

Fitzpatrick Laboratory @FitzpatrickLab Oct 31

zmescience.com/medicine/a-pro…

www.zmescience.com A Protein Structure Linked to Alzheimer's Has a Secret Job in Sperm Scientists have discovered that amyloid fibers in semen can carry RNA into sperm and deliver it to embryos.