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AlphaFold3 is out (and closed source 🤯😠)! So … how well does it do on peptide-protein complexes?
A continuing thread as we run predictions...
A continuing thread as we run predictions...
Ora Furman Lab 🎗
@FurmanLab
Structural basis of peptide-mediated protein communication and function @HebrewU Member of @RosettaCommons. Tweets by lab members.
🦋 furmanlab.bsky.social 🦋
🦋 furmanlab.bsky.social 🦋
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🚨 actifpTM is now in AF3 🚨
Since our new metric, actifpTM, was determined to be the best for predicting success in designed proteins refolded by AF2 (biorxiv.org/content/10.110… by @TimothyPJenkins), we made it available also in AF3!
Since our new metric, actifpTM, was determined to be the best for predicting success in designed proteins refolded by AF2 (biorxiv.org/content/10.110… by @TimothyPJenkins), we made it available also in AF3!
www.biorxiv.org Predicting Experimental Success in De Novo Binder Design: A Meta-Analysis of 3,766 Experimentally... Designing high-affinity de novo protein binders has become increasingly tractable, yet in vitro prioritisation continues to depend on heuristics in the absence of systematic analysis. Here, we... Our work on refining AlphaFold2’s ipTM has been accepted for publication in Bioinformatics @OxfordJournals
We have been questioning why ipTM worsens when docking peptides with disordered flanking regions, and modified the calculation to remove this effect.
Let’s dive in! 👇View quoted post on X
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🚨Excited to share our new work in Cell Reports!
We reveal how SARS-CoV-2 nucleocapsid protein (NP) directs complement attack on uninfected cells, a surprising immune evasion twist.
🔗 cell.com/cell-reports/f…
🚨Excited to share our new work in Cell Reports!
We reveal how SARS-CoV-2 nucleocapsid protein (NP) directs complement attack on uninfected cells, a surprising immune evasion twist.
🔗 cell.com/cell-reports/f…
www.cell.com Transfer of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-media... Using a cell-culture model, Fahoum et al. demonstrate SARS-CoV-2 nucleocapsid protein (NP) spread from infected to neighboring non-susceptible cells. This elicits NP-driven, antibody-dependent... Starts in 10 minutes! This will be exciting, join us!
Join us at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute) and Dr. Jesús Alvardo Valverde (@imbmainz).
Register to attend:
tinyurl.com/PMCseminar2
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