Gene-Wei Li Lab

@GeneWeiLiLab

Gene-Wei Li's lab @MITBiology, studying the quantitative biology of gene expression. Account run by lab members.

gwli.scripts.mit.edu/group/ Joined February 2022

47 Following 761 Followers 56 Posts

Latest posts 5

In our latest study, published in @MolecularCell, we reveal that mRNA sequences hundreds of nucleotides from the start codon can act as potent repressors of gene expression through long-range base pairing to the ribosome binding site (RBS)... (1/4)

Molecular Cell @MolecularCell Sep 19

Long-range mRNA folding shapes expression and sequence of bacterial genes dlvr.it/TVYSVc

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Gene-Wei Li Lab @GeneWeiLiLab Sep 16

Excited to celebrate former Li Lab postdoc @bioSavinov opening his own lab at @UTAustin!

Congratulations to Andrew and the Savinov lab — you're already doing amazing science, and we can't wait to see what's next.

Andrew Savinov @bioSavinov Sep 16

Thrilled to announce that the Savinov lab is now live at @UTAustin! Our lab @UT_MBS employs massively parallel experimental and AI methods to discover and design protein fragments as universal regulators of protein interactions in health and disease. savinovlab.com (1/n)

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Gene-Wei Li Lab @GeneWeiLiLab Jun 17

We're excited to share our latest publication, from graduate student Julia Dierksheide in the lab! In B. subtilis, the fast-moving RNA polymerase outpaces the leading ribosome, leaving mRNA transcripts vulnerable to the transcription termination factor Rho. (1/2)

Gene-Wei Li Lab @GeneWeiLiLab Jun 10

Thrilled to announce our latest work, from postdoctoral fellow Bob Battaglia @RNABob in the lab! Transcription termination is a key determinant of gene expression. However, the sequence grammar defining transcription termination has long been elusive. (1/2)

Gene-Wei Li Lab @GeneWeiLiLab Jun 8

Excited to share our recent work expanding our understanding of transcription termination, from Jenny Cascino in the lab! Here we show that transcription termination in cyanobacteria proceeds largely outside of known, canonical mechanisms.
journals.asm.org/doi/10.1128/ms…
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journals.asm.org Canonical transcription termination mechanisms explain a minority of operons in cyanobacteria |... Our understanding of bacterial transcription regulation is largely based on model organisms like Escherichia coli and Bacillus subtilis, yet many of these mechanisms appear absent or divergent in...