Young Seok Ju

@GenomeDoctor

Genome scientist working at KAIST, Korea, & co-founder of Inocras, USA. Publications available @ scholar.google.co.kr/citations?hl=e…

Daejeon; San Diego julab.kaist.ac.kr Joined September 2011

512 Following 547 Followers 370 Posts

Latest posts 5

Pinned post

Young Seok Ju @GenomeDoctor Oct 29

Our new preprint! Multi-omics of 406 clones reveals that human embryogenesis leaves a strong and lasting epigenetic imprint on the adult colon epithelium, shaping more of its epigenetic heterogeneity than aging process. @hyein_won1 @YunahLee__
researchsquare.com/article/rs-113…

www.researchsquare.com Embryonic origins of epigenetic mosaicism in the human colorectal epithelium Somatic cells can acquire epigenetic changes throughout life, generating epigenetic mosaicism among cells of the same type. However, the extent, timing and persistence of this somatic epimosaicism...

Young Seok Ju @GenomeDoctor Apr 14

I am pleased to share our work on Cavendish bananas, a clonally propagated crop. Using somatic mutations from >100 bananas collected worldwide, we reconstructed their global dissemination history and genetic microevolution under large-scale cultivation.
researchsquare.com/article/rs-919…

www.researchsquare.com Somatic mutations trace the global spread and microevolution of Cavendish bananas Bananas (Musa spp.) are among the earliest domesticated fruit crops, with a cultivation history spanning nearly 10,000 years. Among the hundreds of banana cultivars, the clonally propagated triploid...

Young Seok Ju @GenomeDoctor Dec 3, 2025

I am proud of our work on 1,364 breast cancer whole-genomes with their full medical records just published in Nature (nature.com/articles/s4158…).

www.nature.com Whole-genome landscapes of 1,364 breast cancers Nature - Whole-genome and transcriptome analysis of 1,364 cases of breast cancer from South Korea broadens our understanding of breast cancer biology and reveals genomic features that connect...

Young Seok Ju @GenomeDoctor Oct 7, 2025

We posted a preprint, "Clonal dynamics of monozygotic twinning in early human embryogenesis" biorxiv.org/content/10.110…. This study revealed 3 types of identical twins ( para-, sub-, and full-identical), according to cellular lineage dynamics prior to embryonic splitting. @cjyoon__

www.biorxiv.org Clonal dynamics of monozygotic twinning in early human embryogenesis Monozygotic twins are derived from the split of a single zygote early in embryogenesis. Although it was hypothesized that the timing of twining is overall associated with fetal membrane configuration...

Young Seok Ju @GenomeDoctor Aug 29, 2025

Our work, published in Genome Research this week (pubmed.ncbi.nlm.nih.gov/40858362/), reports that APOBEC3A, not APOBEC3B, is the dominant DNA mutator in human normal cells, surprisingly. Many thanks @HFSP for support, and all authors, particularly Yohan, Ji-Hyun, Joonoh and BK!

pubmed.ncbi.nlm.nih.gov APOBEC3A drives deaminase mutagenesis in human gastric epithelium - PubMed Cancer genomes frequently carry apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC)-associated DNA mutations, suggesting APOBEC enzymes as innate mutagens during cancer initiation and...