Geodesic Intelligence

Introducing NovaAtom-Lite, an all-atom structure prediction model for drug discovery.

It predicts the structures of proteins, nucleic acids, and the molecules they bind, including how they fit together.

NovaAtom-Lite outperforms both IsoDDE and AlphaFold 3 on FoldBench antibody–antigen structure prediction (DockQ ≥ 0.23):

NovaAtom-Lite: 79.07% (n=172)

IsoDDE: 75.58%

AlphaFold 3: 47.90% (n=167)

Our evaluation uses 5 seeds × 5 samples, with the top-1 prediction selected by the model's own ranking score.

Better structure prediction. A stronger starting point for your next experiment.

Live today via Geodesic API and NovaDDE.

🔗 API: platform.geodesiclab.com

🔗 NovaDDE: agent.geodesiclab.com

🔗 Model Card: geodesiclab.com/news/introduci…

Excited to partner with @GenScript to launch the Beyond Binding Challenge! 🧬

AI-designed antibodies need to go beyond binding affinity to become real therapeutics.

Let's push the boundaries of AI-driven antibody design and turn computational breakthroughs into real-world impact.

Up to $2.5M in awards. Stay tuned!

What does an AI-native workflow for protein binder design look like in practice?

In our latest post, we walk through a pilot design run using NovaDDE:

Given a target, the AI agent analyzes the design problem, helps select an epitope and design approach, submits the job, and guides the computational evaluation of the resulting candidates.

We also share some of the directions we’re exploring as we continue to develop the workflow.

A closer look at NovaDDE and where we’re taking it next:

geodesiclab.com/news/novadde-a…

Today, we’re launching the Geodesic API Platform.
geodesiclab.com/api

For the first time, Geodesic is making our AI models and drug discovery capabilities available through APIs.

At its core is NovaAtom, our in-house model for predicting the structures of proteins, small molecules, nucleic acids, and their interactions.

Now available in Lite Preview, this is the first time NovaAtom has been made available beyond Geodesic’s own discovery platform.

Alongside NovaAtom, we’ve integrated the field’s core models — carefully curated and continuously updated.

To use the API:

curl -X POST platform.geodesiclab.com/api/jobs \
-H "Authorization: Bearer $GEODESIC_API_KEY" \
-F "model=novaatom" \
-F 'params={"jobName":"rbd-nanobody","sequences":">rbd\nTNLCPFGEVFNATRFASV...\n>nb\nQVQLVESGGGLVQAGGSLR..."}'
Poll the job, pull the results, and feed them directly into the next model.

Your AI assistant can use the platform directly, too. Connect Claude Code, Codex, or your own agent with one URL and an API key.

We manage the integrations and handoffs. You focus on the science.

Understand biology. Predict structures. Design proteins. Discover molecules.

One key. One interface.

Start building today!

NovaDDE Plus is now live!

Built for scientists who use AI for drug discovery every day — more compute, priority access, concurrent runs, API access, and end-to-end campaign execution.

$30/month and sign up by September 25 to get your first month free.

Our goal is simple: put the most powerful AI for drug discovery into the hands of every scientist.

geodesiclab.com/pricing