Ghayas Issa

@GhayasIssa

Leukemia Physician at MD Anderson. Research in AML, CML, other leukemias if it's the right genotype. Views expressed here are my own.

faculty.mdanderson.org/profiles/ghaya… Joined April 2017

294 Following 793 Followers 153 Posts

Latest posts 5

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Ghayas Issa @GhayasIssa Mar 15, 2023

Surreal to play a role in this relay race. Below proof that menin inhibition works. A new targeted therapy in leukemia published @Nature
nature.com/articles/s4158… @MDAndersonNews

www.nature.com The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia Nature - Revumenib, a potent and selective oral inhibitor of the menin–KMT2A interaction, is associated with a low frequency of treatment-related adverse events and promising clinical...

Ghayas Issa @GhayasIssa Nov 15, 2024

Menin inhibition is a standard of care! FDA approval of revumenib!! So happy to see that the benefit witnessed in patients on study is leading to a medicine to all who need it. Ready to forj ahead with more to come! ;)

Ghayas Issa @GhayasIssa Nov 5, 2024

The first BTC trial to target AML MRD with combination of menin and BCL2 inhibition is now open! Huge team effort and more exciting trials for MRD to come. Goal is to better measure, understand and treat MRD

𝗕𝗿𝗲𝗮𝗸 𝙏𝙝𝙧𝙤𝙪𝙜𝙝 𝗖𝗮𝗻𝗰𝗲𝗿 Verified account @break_cancer Nov 5, 2024

We’ve enrolled the first patient in a phase 2 clinical trial targeting minimal residual disease in #AML, hoping to prevent relapse by eliminating lingering cancer cells. #RadicalCollaboration
@GhayasIssa @MDAndersonNews

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Ghayas Issa @GhayasIssa Aug 9, 2024

Revumenib phase 2 for R/R KMT2Ar finally out! ORR 63%, CR/CRh 23%, MRD neg 70%. Result filed for FDA approval

ascopubs.org/doi/10.1200/JC…

ascopubs.org Menin Inhibition With Revumenib for KMT2A-Rearranged Relapsed or Refractory Acute Leukemia (AUGME... PURPOSERevumenib, an oral, small molecule inhibitor of the menin-lysine methyltransferase 2A (KMT2A) interaction, showed promising efficacy and safety in a phase I study of heavily pretreated...

Ghayas Issa @GhayasIssa Jul 9, 2024

A pleasure to do this on differentiation syndrome with Eytan and Courtney. A thread 🧵

ashpublications.org/blood/article-…