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Among comatose survivors of out-of-hospital #CardiacArrest treated with #TherapeuticHypothermia at 33 °C, increasing cooling duration did not improve neurological outcomes or mortality.
ja.ma/3RTXrncView quoted post on X
On the latest episode of "In the Interim…" Dr. Scott Berry and Dr. Will Meurer break down the ICECAP trial design, an innovative, Bayesian, adaptive trial in cardiac arrest research.
ICECAP studies therapeutic hypothermia duration across 10 different cooling periods (6-72 hours) in two patient populations using Bayesian duration-response modeling and response-adaptive randomization. The trial addresses a critical clinical question: how long should we cool patients after cardiac arrest to protect brain function?
Key design features:
✅️ No zero-cooling arm (standard of care made this impossible)
✅️ Weighted mRS outcome measure capturing full recovery spectrum
✅️ Adaptive analyses every 50 patients
✅️ Population-specific allocation for shockable vs. non-shockable rhythms
Results coming soon! This episode covers the design process, the clinical rationale, and the statistical innovation that made ICECAP possible. The results will be a future episode.
Hear about this fascinating design today: berryconsultants.com/resource/63-ic…View quoted post on X
Okay. A bit late to the 4th birthday! Got the protocol paper preprint up researchsquare.com/article/rs-403… @willmeurer @nih_nhlbi @NINDSdirector @NINDStrials #siren #cardiacarrestView quoted post on X
