Pinned post
Congratulations to Dr @J_Marotta for awesome an PhD defense today!! @EmoryMMG @EmoryMicrobio @EmoryARC
Grabowicz lab
@GrabowiczLab
Bacterial genetics lab interested in antibiotic resistance @EmoryUniversity 🇦🇺🇺🇸
300 Following 509 Followers 161 Posts
Latest posts 5
Unlike Boeings, LolCDE is built tough. Took a lot to break this lipoprotein transporter! See the latest from the lab in @mbiojournal journals.asm.org/doi/10.1128/mb…
journals.asm.org Genetic analysis reveals a robust and hierarchical recruitment of the LolA chaperone to the LolCDE... Resistance to current antibiotics is increasingly common. New antibiotics that target essential processes are needed to expand clinical options. For Gram-negative bacteria, their cell surface—the... Congratulations to Dr Hannah Smith from @GrabowiczLab who was awarded her PhD today!!! Awesome!!!
Our first #AlphaFold wow moment! Lipoproteins like NlpE detect cell envelope stress, but how? @J_Marotta decided to find out, discovering a key loop in NlpE. Mutants can’t activate the CpxA sensor kinase to signal stress.
onlinelibrary.wiley.com/doi/abs/10.111…
onlinelibrary.wiley.com/doi/abs/10.111…
onlinelibrary.wiley.com Molecular insights into Escherichia coli Cpx envelope stress response activation by the sensor... We reveal the molecular details of how the sensor lipoprotein NlpE activates the Cpx two-component stress response. Through complementary genetics, biochemistry, and AlphaFold2 modeling, we identif... Elegant solution for a big problem. Very nice work
OUT NOW @NatureView quoted post on X
👀Coordination of bacterial cell wall and outer membrane biosynthesis
nature.com/articles/s4158…
