Hlib Razumkov @HRazumkov · Nov 6, 2024, Nov 6, 2024, 6:40 AM Happy to announce that our work on selective WEE1 molecular glue degraders has been accepted in JACS!pubs.acs.org/doi/abs/10.102… pubs.acs.org Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial... Abstract. Small molecules promoting protein–protein interactions produce a range of therapeutic outcomes. Molecular glue degraders exemplify this concept d
Hlib Razumkov @HRazumkov · May 6, 2024, May 6, 2024, 8:07 AM Excited to share our work on the CRBN-dependent molecular glue degraders of WEE1 derived from a multicomponent library!biorxiv.org/content/10.110… www.biorxiv.org Discovery of CRBN-dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial... Small molecules promoting protein-protein interactions produce a range of therapeutic outcomes. Molecular glue degraders exemplify this concept due to their compact drug-like structures and ability...